1-N-(3,3-dimethylbut-1-yl)-2,4-dioxo-5-N-(2-fluorophenyl)-3-(phenyloxycarbonylamino)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

Base Information

Chemical Name:1-N-(3,3-dimethylbut-1-yl)-2,4-dioxo-5-N-(2-fluorophenyl)-3-(phenyloxycarbonylamino)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine
CAS No.:151620-16-5
Molecular Formula:C₂₈H₂₈FN₃O₄
Molecular Weight:489.546
Hs Code.:

Synonyms:1-N-(3,3-dimethylbut-1-yl)-2,4-dioxo-5-N-(2-fluorophenyl)-3-(phenyloxycarbonylamino)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

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Chemical Property of 1-N-(3,3-dimethylbut-1-yl)-2,4-dioxo-5-N-(2-fluorophenyl)-3-(phenyloxycarbonylamino)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

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Technology Process of 1-N-(3,3-dimethylbut-1-yl)-2,4-dioxo-5-N-(2-fluorophenyl)-3-(phenyloxycarbonylamino)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

There total 5 articles about 1-N-(3,3-dimethylbut-1-yl)-2,4-dioxo-5-N-(2-fluorophenyl)-3-(phenyloxycarbonylamino)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1885-14-9
phenyl chloroformate

: 151620-61-0
3-amino-1-N-(3,3-dimethylbut-1-yl)-2,4-dioxo-5-N-(2-fluorophenyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

: 151620-16-5
1-N-(3,3-dimethylbut-1-yl)-2,4-dioxo-5-N-(2-fluorophenyl)-3-(phenyloxycarbonylamino)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

Guidance literature:: With pyridine; In dichloromethane; at 23 ℃; for 0.5h;
DOI:10.1021/jm990967h

Reference yield:

: 2987-16-8
3,3-dimethylbutyrylaldehyde

: 151620-16-5
1-N-(3,3-dimethylbut-1-yl)-2,4-dioxo-5-N-(2-fluorophenyl)-3-(phenyloxycarbonylamino)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

Guidance literature:: Multi-step reaction with 4 steps

1: 65 percent / NaBH₄; CH₃COONa*3H₂O / acetic acid; H₂O; ethanol / 0.5 h / 23 °C

2: tetrahydrofuran / 3 h / 50 °C

3: Zn; AcOH / 3 h / 23 °C

4: pyridine / CH₂Cl₂ / 0.5 h / 23 °C

With pyridine; sodium tetrahydroborate; sodium acetate; acetic acid; zinc; In tetrahydrofuran; ethanol; dichloromethane; water; acetic acid; 1: Reductive alkylation / 2: Acylation / 3: Reduction / 4: Acylation;
DOI:10.1021/jm990967h

Reference yield:

: 28898-03-5
N-(2-fluorophenyl)benzene-1,2-diamine

: 151620-16-5
1-N-(3,3-dimethylbut-1-yl)-2,4-dioxo-5-N-(2-fluorophenyl)-3-(phenyloxycarbonylamino)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

Guidance literature:: Multi-step reaction with 4 steps

1: 65 percent / NaBH₄; CH₃COONa*3H₂O / acetic acid; H₂O; ethanol / 0.5 h / 23 °C

2: tetrahydrofuran / 3 h / 50 °C

3: Zn; AcOH / 3 h / 23 °C

4: pyridine / CH₂Cl₂ / 0.5 h / 23 °C

With pyridine; sodium tetrahydroborate; sodium acetate; acetic acid; zinc; In tetrahydrofuran; ethanol; dichloromethane; water; acetic acid; 1: Reductive alkylation / 2: Acylation / 3: Reduction / 4: Acylation;
DOI:10.1021/jm990967h