Technology Process of (3S)-3-benzyloxycarbonylaminoglutaryl-(S)-alanine dimethyl ester
There total 4 articles about (3S)-3-benzyloxycarbonylaminoglutaryl-(S)-alanine dimethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) ammonium acetate, molecular sieves 3 Angstroem, 2.) methanolic HCl, NaBH3CN / 1.) methanol, 2 d, 2.) pH 3, r.t., 1 h
2: 84 percent / aq. NaHCO3 / toluene / 3 h / Ambient temperature
3: 82 percent / phosphate buffer, aq. NaOH / pig liver esterase / acetone / 7 h / 25 °C / pH 8
4: 1.) K2CO3, 2.) 2-isobutyloxy-1-isobutyloxycarbonyl-1,2-dihydroquinoline / 1.) water, 2a.) THF, r.t., 18 h, 2b.) reflux, 2 h
With
ammonium acetate; hydrogenchloride; sodium hydroxide; phosphate buffer; 2-isobutoxy-1-isobutoxycarbonyl-1,2-dihydroquinoline; 3 A molecular sieve; sodium cyanoborohydride; sodium hydrogencarbonate; potassium carbonate;
pig liver esterase;
In
acetone; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 84 percent / aq. NaHCO3 / toluene / 3 h / Ambient temperature
2: 82 percent / phosphate buffer, aq. NaOH / pig liver esterase / acetone / 7 h / 25 °C / pH 8
3: 1.) K2CO3, 2.) 2-isobutyloxy-1-isobutyloxycarbonyl-1,2-dihydroquinoline / 1.) water, 2a.) THF, r.t., 18 h, 2b.) reflux, 2 h
With
sodium hydroxide; phosphate buffer; 2-isobutoxy-1-isobutoxycarbonyl-1,2-dihydroquinoline; sodium hydrogencarbonate; potassium carbonate;
pig liver esterase;
In
acetone; toluene;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 82 percent / phosphate buffer, aq. NaOH / pig liver esterase / acetone / 7 h / 25 °C / pH 8
2: 1.) K2CO3, 2.) 2-isobutyloxy-1-isobutyloxycarbonyl-1,2-dihydroquinoline / 1.) water, 2a.) THF, r.t., 18 h, 2b.) reflux, 2 h
With
sodium hydroxide; phosphate buffer; 2-isobutoxy-1-isobutoxycarbonyl-1,2-dihydroquinoline; potassium carbonate;
pig liver esterase;
In
acetone;
