(3R)-3-benzyloxycarbonylaminoglutaryl-(S)-alanine

Base Information

Chemical Name:(3R)-3-benzyloxycarbonylaminoglutaryl-(S)-alanine
CAS No.:130737-75-6
Molecular Formula:C₁₆H₂₀N₂O₇
Molecular Weight:352.344
Hs Code.:

Synonyms:

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Chemical Property of (3R)-3-benzyloxycarbonylaminoglutaryl-(S)-alanine

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Technology Process of (3R)-3-benzyloxycarbonylaminoglutaryl-(S)-alanine

There total 12 articles about (3R)-3-benzyloxycarbonylaminoglutaryl-(S)-alanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 130737-74-5
(3S)-3-benzyloxycarbonylaminoglutaryl-(S)-alanine dimethyl ester

: 130737-75-6,130737-77-8
(3S)-3-benzyloxycarbonylaminoglutaryl-(S)-alanine

Guidance literature:: With sodium hydroxide; In methanol; at 0 ℃; for 1.5h;

Reference yield: 76.0%

: 130737-76-7
(3R)-3-benzyloxycarbonylaminoglutaryl-(S)-alanine di-t-butyl ester

: 130737-75-6,130737-77-8
(3R)-3-benzyloxycarbonylaminoglutaryl-(S)-alanine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 1.5h; Ambient temperature;

Reference yield:

: 1830-54-2
3-oxopentanedioic acid dimethyl ester

: 130737-75-6,130737-77-8
(3S)-3-benzyloxycarbonylaminoglutaryl-(S)-alanine

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) ammonium acetate, molecular sieves 3 Angstroem, 2.) methanolic HCl, NaBH₃CN / 1.) methanol, 2 d, 2.) pH 3, r.t., 1 h

2: 84 percent / aq. NaHCO₃ / toluene / 3 h / Ambient temperature

3: 82 percent / phosphate buffer, aq. NaOH / pig liver esterase / acetone / 7 h / 25 °C / pH 8

4: 1.) K₂CO₃, 2.) 2-isobutyloxy-1-isobutyloxycarbonyl-1,2-dihydroquinoline / 1.) water, 2a.) THF, r.t., 18 h, 2b.) reflux, 2 h

5: 82 percent / aq. NaOH / methanol / 1.5 h / 0 °C

With ammonium acetate; hydrogenchloride; sodium hydroxide; phosphate buffer; 2-isobutoxy-1-isobutoxycarbonyl-1,2-dihydroquinoline; 3 A molecular sieve; sodium cyanoborohydride; sodium hydrogencarbonate; potassium carbonate; pig liver esterase; In methanol; acetone; toluene;