(1H-benzo[d]imidazol-2-yl)(4-(2-((4-methoxybenzyl)(pyridin-2-yl)amino)ethyl)piperazin-1-yl)methanone

Base Information

Chemical Name:(1H-benzo[d]imidazol-2-yl)(4-(2-((4-methoxybenzyl)(pyridin-2-yl)amino)ethyl)piperazin-1-yl)methanone
CAS No.:1345012-40-9
Molecular Formula:C₂₇H₃₀N₆O₂
Molecular Weight:470.574
Hs Code.:

Synonyms:(1H-benzo[d]imidazol-2-yl)(4-(2-((4-methoxybenzyl)(pyridin-2-yl)amino)ethyl)piperazin-1-yl)methanone

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Chemical Property of (1H-benzo[d]imidazol-2-yl)(4-(2-((4-methoxybenzyl)(pyridin-2-yl)amino)ethyl)piperazin-1-yl)methanone

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Technology Process of (1H-benzo[d]imidazol-2-yl)(4-(2-((4-methoxybenzyl)(pyridin-2-yl)amino)ethyl)piperazin-1-yl)methanone

There total 5 articles about (1H-benzo[d]imidazol-2-yl)(4-(2-((4-methoxybenzyl)(pyridin-2-yl)amino)ethyl)piperazin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2849-93-6
2-benzimidazolecarboxylic acid

: 1356537-64-8
N-(4-methoxybenzyl)-N-(2-(piperazin-1-yl)ethyl)pyridin-2-ylamine

: 1345012-40-9
(1H-benzo[d]imidazol-2-yl)(4-(2-((4-methoxybenzyl)(pyridin-2-yl)amino)ethyl)piperazin-1-yl)methanone

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In acetonitrile; for 3h;
DOI:10.1016/j.bmcl.2011.09.001

Reference yield:

: 103-76-4
1-(2-hydroxyethyl)piperazine

: 1345012-40-9
(1H-benzo[d]imidazol-2-yl)(4-(2-((4-methoxybenzyl)(pyridin-2-yl)amino)ethyl)piperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1: dichloromethane / 1 h / 20 °C

2: iodine; triphenylphosphine / dichloromethane / 20 h

3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h

4: trifluoroacetic acid / dichloromethane / 1 h

5: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / acetonitrile / 3 h

With iodine; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; triphenylphosphine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1016/j.bmcl.2011.09.001

Reference yield:

: 1345012-36-3
tert-butyl 4-(2-((4-methoxybenzyl)(pyridin-2-yl)amino)ethyl)piperazine-1-carboxylate

: 1345012-40-9
(1H-benzo[d]imidazol-2-yl)(4-(2-((4-methoxybenzyl)(pyridin-2-yl)amino)ethyl)piperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 1 h

2: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / acetonitrile / 3 h

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; trifluoroacetic acid; In dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2011.09.001