dimethyl (3-(2-(tert-butyldimethylsilyloxy)phenyl)-2-oxopropyl)phosphonate

Base Information

Chemical Name:dimethyl (3-(2-(tert-butyldimethylsilyloxy)phenyl)-2-oxopropyl)phosphonate
CAS No.:1448439-17-5
Molecular Formula:C₁₇H₂₉O₅PSi
Molecular Weight:372.474
Hs Code.:

Synonyms:dimethyl (3-(2-(tert-butyldimethylsilyloxy)phenyl)-2-oxopropyl)phosphonate

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Chemical Property of dimethyl (3-(2-(tert-butyldimethylsilyloxy)phenyl)-2-oxopropyl)phosphonate

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Technology Process of dimethyl (3-(2-(tert-butyldimethylsilyloxy)phenyl)-2-oxopropyl)phosphonate

There total 3 articles about dimethyl (3-(2-(tert-butyldimethylsilyloxy)phenyl)-2-oxopropyl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1448439-16-4
dimethyl (3-(2-hydroxyphenyl)-2-oxopropyl)phosphonate

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1448439-17-5
dimethyl (3-(2-(tert-butyldimethylsilyloxy)phenyl)-2-oxopropyl)phosphonate

Guidance literature:: With 1H-imidazole; dmap; In N,N-dimethyl-formamide; at 20 ℃; for 18h; Inert atmosphere;
DOI:10.1039/c3ob41065j

Reference yield:

: 614-75-5
2-Hydroxyphenylacetic acid

: 1448439-17-5
dimethyl (3-(2-(tert-butyldimethylsilyloxy)phenyl)-2-oxopropyl)phosphonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuric acid / 3 h / Heating; Inert atmosphere; Reflux

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 °C / Inert atmosphere

3.1: 1H-imidazole; dmap / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

With 1H-imidazole; dmap; n-butyllithium; sulfuric acid; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1039/c3ob41065j

Reference yield:

: 22446-37-3
methyl (2-hydroxyphenyl)acetate

: 1448439-17-5
dimethyl (3-(2-(tert-butyldimethylsilyloxy)phenyl)-2-oxopropyl)phosphonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 °C / Inert atmosphere

2.1: 1H-imidazole; dmap / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

With 1H-imidazole; dmap; n-butyllithium; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1039/c3ob41065j