tert-butyl 2-(4-((2-methoxy-6-phenylpyridin-3-yl)methoxy)phenoxy)-ethanoate

Base Information

• Chemical Name: tert-butyl 2-(4-((2-methoxy-6-phenylpyridin-3-yl)methoxy)phenoxy)-ethanoate
• CAS No.: 1202164-41-7
• Molecular Formula: C₂₅H₂₇NO₅
• Molecular Weight: 421.493
• Mol file: 1202164-41-7.mol

Synonyms:tert-butyl 2-(4-((2-methoxy-6-phenylpyridin-3-yl)methoxy)phenoxy)-ethanoate

Chemical Property of tert-butyl 2-(4-((2-methoxy-6-phenylpyridin-3-yl)methoxy)phenoxy)-ethanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 2-(4-((2-methoxy-6-phenylpyridin-3-yl)methoxy)phenoxy)-ethanoate

There total 4 articles about tert-butyl 2-(4-((2-methoxy-6-phenylpyridin-3-yl)methoxy)phenoxy)-ethanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

(2-methoxy-6-phenylpyridin-3-yl)methanol (1202163-53-8) + tert-butyl 2-(4-hydroxyphenoxy)acetate (42806-92-8) → tert-butyl 2-(4-((2-methoxy-6-phenylpyridin-3-yl)methoxy)phenoxy)-ethanoate (1202164-41-7)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

Reference yield:

Methyl 1,2-Dihydro-2-oxo-6-phenyl-3-pyridinecarboxylate (125031-47-2) → tert-butyl 2-(4-((2-methoxy-6-phenylpyridin-3-yl)methoxy)phenoxy)-ethanoate (1202164-41-7)

Guidance literature:

Multi-step reaction with 3 steps

1: silver(l) oxide / toluene / 50 - 70 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; triphenylphosphine; silver(l) oxide; In tetrahydrofuran; toluene;

Reference yield:

methyl 2-methoxy-6-phenyl-pyridine-3-carboxylate (85815-01-6) → tert-butyl 2-(4-((2-methoxy-6-phenylpyridin-3-yl)methoxy)phenoxy)-ethanoate (1202164-41-7)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran;

upstream raw materials:

(2-methoxy-6-phenylpyridin-3-yl)methanol

tert-butyl 2-(4-hydroxyphenoxy)acetate

Methyl 1,2-Dihydro-2-oxo-6-phenyl-3-pyridinecarboxylate

methyl 2-carbamoyl-5-dimethylamino-5-phenylpentane-2,4-dienoate