2-(4-benzyloxy-3-methoxy-phenyl)-1-[5-benzyloxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-ethyl acetate

Base Information

Chemical Name:2-(4-benzyloxy-3-methoxy-phenyl)-1-[5-benzyloxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-ethyl acetate
CAS No.:1374004-92-8
Molecular Formula:C₄₀H₃₇NO₇S
Molecular Weight:675.802
Hs Code.:

Synonyms:2-(4-benzyloxy-3-methoxy-phenyl)-1-[5-benzyloxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-ethyl acetate

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Chemical Property of 2-(4-benzyloxy-3-methoxy-phenyl)-1-[5-benzyloxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-ethyl acetate

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Technology Process of 2-(4-benzyloxy-3-methoxy-phenyl)-1-[5-benzyloxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-ethyl acetate

There total 4 articles about 2-(4-benzyloxy-3-methoxy-phenyl)-1-[5-benzyloxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-ethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1374004-91-7
2-(4-benzyloxy-3-methoxy-phenyl)-1-[5-benzyloxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-ethanol

: 75-36-5
acetyl chloride

: 1374004-92-8
2-(4-benzyloxy-3-methoxy-phenyl)-1-[5-benzyloxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-ethyl acetate

Guidance literature:: With pyridine; In dichloromethane; at 0 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.tet.2012.03.026

Reference yield:

: 2426-87-1
3-methoxy-4-(phenylmethoxy)benzaldehyde

: 1374004-92-8
2-(4-benzyloxy-3-methoxy-phenyl)-1-[5-benzyloxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-ethyl acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium tert-butylate / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

2.1: hydrogenchloride / tetrahydrofuran; water / 1 h / Reflux

3.1: propionic acid; phenylboronic acid / toluene / 20 h / Reflux

3.2: 0.5 h / 0 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

5.1: pyridine / dichloromethane / 2 h / 0 °C / Inert atmosphere

With pyridine; hydrogenchloride; potassium tert-butylate; potassium carbonate; propionic acid; phenylboronic acid; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tet.2012.03.026

Reference yield:

: 16209-52-2
<4-(benzyloxy)-3-methoxyphenyl>acetaldehyde

: 1374004-92-8
2-(4-benzyloxy-3-methoxy-phenyl)-1-[5-benzyloxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-ethyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: propionic acid; phenylboronic acid / toluene / 20 h / Reflux

1.2: 0.5 h / 0 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

3.1: pyridine / dichloromethane / 2 h / 0 °C / Inert atmosphere

With pyridine; potassium carbonate; propionic acid; phenylboronic acid; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tet.2012.03.026