methyl 4-(benzyl(3-methoxy-3-oxo-2-phenylpropyl)amino)butanoate

Base Information

• Chemical Name: methyl 4-(benzyl(3-methoxy-3-oxo-2-phenylpropyl)amino)butanoate
• CAS No.: 1356654-17-5
• Molecular Formula: C₂₂H₂₇NO₄
• Molecular Weight: 369.461
• Mol file: 1356654-17-5.mol

Synonyms:methyl 4-(benzyl(3-methoxy-3-oxo-2-phenylpropyl)amino)butanoate

Chemical Property of methyl 4-(benzyl(3-methoxy-3-oxo-2-phenylpropyl)amino)butanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-(benzyl(3-methoxy-3-oxo-2-phenylpropyl)amino)butanoate

There total 3 articles about methyl 4-(benzyl(3-methoxy-3-oxo-2-phenylpropyl)amino)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

Methyl 4-bromobutyrate (4897-84-1) + methyl 3-(benzylamino)-2-phenylpropanoate (101584-49-0) → methyl 4-(benzyl(3-methoxy-3-oxo-2-phenylpropyl)amino)butanoate (1356654-17-5)

Guidance literature:

With potassium carbonate; potassium iodide; In 1,4-dioxane; water; at 100 ℃; for 64h;

DOI:10.1016/j.tetlet.2011.11.129

Reference yield:

2-phenyl-acrylic acid methyl ester (1865-29-8) → methyl 4-(benzyl(3-methoxy-3-oxo-2-phenylpropyl)amino)butanoate (1356654-17-5)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 18 h / 20 °C

2: potassium carbonate; potassium iodide / 1,4-dioxane; water / 64 h / 100 °C

With potassium carbonate; potassium iodide; In 1,4-dioxane; methanol; water;

DOI:10.1016/j.tetlet.2011.11.129

Reference yield:

benzeneacetic acid methyl ester (101-41-7) → methyl 4-(benzyl(3-methoxy-3-oxo-2-phenylpropyl)amino)butanoate (1356654-17-5)

Guidance literature:

Multi-step reaction with 3 steps

1: tetra-(n-butyl)ammonium iodide; potassium carbonate / water; N,N-dimethyl-formamide / 1.5 h / 80 °C

2: methanol / 18 h / 20 °C

3: potassium carbonate; potassium iodide / 1,4-dioxane; water / 64 h / 100 °C

With tetra-(n-butyl)ammonium iodide; potassium carbonate; potassium iodide; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2011.11.129

upstream raw materials:

Methyl 4-bromobutyrate

methyl 3-(benzylamino)-2-phenylpropanoate

2-phenyl-acrylic acid methyl ester

benzeneacetic acid methyl ester

Downstream raw materials:

t-butyl 5-((dimethylamino)methylene)-4-oxo-3-phenylazepane-1-carboxylate

t-butyl 4-oxo-3-phenylazepane-1-carboxylate

methyl 4-(t-butoxycarbonyl(3-methoxy-3-oxo-2-phenylpropyl)amino)butanoate