Benzoic acid (2S,3S,4S,5S,6R,8R,9R,11R)-9-benzyloxy-8-[(S)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2-ethyl-3-methoxymethoxy-3,5,9,11-tetramethyl-1,7-dioxa-spiro[5.5]undec-4-yl ester

Base Information

Chemical Name:Benzoic acid (2S,3S,4S,5S,6R,8R,9R,11R)-9-benzyloxy-8-[(S)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2-ethyl-3-methoxymethoxy-3,5,9,11-tetramethyl-1,7-dioxa-spiro[5.5]undec-4-yl ester
CAS No.:99285-02-6
Molecular Formula:C₅₀H₆₆O₈Si
Molecular Weight:823.155
Hs Code.:

Benzoic acid (2S,3S,4S,5S,6R,8R,9R,11R)-9-benzyloxy-8-[(S)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2-ethyl-3-methoxymethoxy-3,5,9,11-tetramethyl-1,7-dioxa-spiro[5.5]undec-4-yl ester

Synonyms:Benzoic acid (2S,3S,4S,5S,6R,8R,9R,11R)-9-benzyloxy-8-[(S)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2-ethyl-3-methoxymethoxy-3,5,9,11-tetramethyl-1,7-dioxa-spiro[5.5]undec-4-yl ester

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Chemical Property of Benzoic acid (2S,3S,4S,5S,6R,8R,9R,11R)-9-benzyloxy-8-[(S)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2-ethyl-3-methoxymethoxy-3,5,9,11-tetramethyl-1,7-dioxa-spiro[5.5]undec-4-yl ester

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Technology Process of Benzoic acid (2S,3S,4S,5S,6R,8R,9R,11R)-9-benzyloxy-8-[(S)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2-ethyl-3-methoxymethoxy-3,5,9,11-tetramethyl-1,7-dioxa-spiro[5.5]undec-4-yl ester

There total 11 articles about Benzoic acid (2S,3S,4S,5S,6R,8R,9R,11R)-9-benzyloxy-8-[(S)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2-ethyl-3-methoxymethoxy-3,5,9,11-tetramethyl-1,7-dioxa-spiro[5.5]undec-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 100-39-0
benzyl bromide

: 99285-01-5
Benzoic acid (2S,3S,4S,5S,6R,8R,9R,11R)-8-[(S)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2-ethyl-9-hydroxy-3-methoxymethoxy-3,5,9,11-tetramethyl-1,7-dioxa-spiro[5.5]undec-4-yl ester

: 99285-02-6
Benzoic acid (2S,3S,4S,5S,6R,8R,9R,11R)-9-benzyloxy-8-[(S)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2-ethyl-3-methoxymethoxy-3,5,9,11-tetramethyl-1,7-dioxa-spiro[5.5]undec-4-yl ester

Guidance literature:: With potassium hexamethylsilazane; In tetrahydrofuran; at 0 - 25 ℃; for 0.333333h;
DOI:10.1139/v85-468

Reference yield:

: 99300-05-7,107437-45-6,107437-46-7
(3S,5R,6S,8S,9R,10S,11S)-8-Ethyl-9,10-dihydroxy-5,9,11-trimethyl-3-phenylselanyl-1,7-dioxa-spiro[5.5]undecane-3-carboxylic acid methyl ester

: 99285-02-6
Benzoic acid (2S,3S,4S,5S,6R,8R,9R,11R)-9-benzyloxy-8-[(S)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2-ethyl-3-methoxymethoxy-3,5,9,11-tetramethyl-1,7-dioxa-spiro[5.5]undec-4-yl ester

Guidance literature:: Multi-step reaction with 9 steps

1: H₂O₂ / pyridine; CH₂Cl₂ / 25 deg C, 30 min, 45 deg C, 30 min

2: 90 percent / LAH / tetrahydrofuran / 2 h / 0 - 25 °C

3: 99 percent / triethylamine, DMAP / 1 h / 25 °C

4: 90 percent / diisopropylethylamine / CH₂Cl₂ / 4 h / 50 °C

6: 90 percent / LAH / tetrahydrofuran / 0 deg C, 5 min, 25 deg C, 1 h

7: 95 percent / imidazole / dimethylformamide / 1 h / 25 °C

8: 78 percent / pyridine / 24 h / 70 °C

9: 92 percent / ((CH₃)3Si)2NK / tetrahydrofuran / 0.33 h / 0 - 25 °C

With pyridine; 1H-imidazole; dmap; lithium aluminium tetrahydride; dihydrogen peroxide; potassium hexamethylsilazane; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; pyridine; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1139/v85-468

Reference yield:

: 98-88-4
benzoyl chloride

: 99285-02-6
Benzoic acid (2S,3S,4S,5S,6R,8R,9R,11R)-9-benzyloxy-8-[(S)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2-ethyl-3-methoxymethoxy-3,5,9,11-tetramethyl-1,7-dioxa-spiro[5.5]undec-4-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / pyridine / 24 h / 70 °C

2: 92 percent / ((CH₃)3Si)2NK / tetrahydrofuran / 0.33 h / 0 - 25 °C

With pyridine; potassium hexamethylsilazane; In tetrahydrofuran;
DOI:10.1139/v85-468