C₄₀H₄₂N₂O₇

Base Information

• Chemical Name: C₄₀H₄₂N₂O₇
• CAS No.: 851121-91-0
• Molecular Formula: C₄₀H₄₂N₂O₇
• Molecular Weight: 662.783
• Mol file: 851121-91-0.mol

Synonyms:C₄₀H₄₂N₂O₇

Chemical Property of C₄₀H₄₂N₂O₇

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₀H₄₂N₂O₇

There total 30 articles about C₄₀H₄₂N₂O₇ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

C40H44N2O8 (851122-05-9) → C40H42N2O7 (851121-91-0)

Guidance literature:

With camphor-10-sulfonic acid; In benzene; at 80 ℃; for 4h;

Reference yield:

2-hydroxymethyl-3-iodo-6-methoxy-5-methyl-phenol (351379-10-7) → C40H42N2O7 (851121-91-0)

Guidance literature:

Multi-step reaction with 13 steps

1.1: 85 percent / K₂CO₃ / acetone / 4 h / Heating

2.1: sodium hydride / tetrahydrofuran; dimethylformamide / 0.17 h / 0 °C

2.2: 99 percent / TBAI / tetrahydrofuran; dimethylformamide / 12 h / 20 °C

3.1: 87 percent / TEA; TBABr; (o-tolyl)3P / Pd(OAc)2 / acetonitrile / 12 h / 80 °C

4.1: 93 percent / H₂; Rh[(COD)-(S,S)-Et-DuPhos]⁽¹⁺⁾*TfO^(1-) / CH₂Cl₂; methanol / 72 h / 20 °C / 5171.48 Torr

5.1: 93 percent / aq. LiOH / methanol; tetrahydrofuran / 11 h / 20 °C

6.1: 82 percent / sodium hydride / tetrahydrofuran / 15 h / 20 °C

7.1: BOPCl; TEA / CH₂Cl₂ / 72 h / 20 °C

8.1: DDQ; aq. buffer / CH₂Cl₂ / 0.5 h / 20 °C / pH 7.00

9.1: 84 percent / Dess-Martin periodinane; 2,6-lutidine / CH₂Cl₂ / 12 h / 20 °C

10.1: 59 percent / HCO₂H / 0.2 h / 100 °C

11.1: NaBH₄ / tetrahydrofuran; H₂O / 2 h / 20 °C

12.1: 80 percent / acetic acid; Bu₃SnH; (Ph₃P)2PdCl₂ / CH₂Cl₂ / 0.5 h / 20 °C

13.1: p-TsOH; MgSO₄ / benzene / 4 h / 85 °C

With 2,6-dimethylpyridine; bis-triphenylphosphine-palladium(II) chloride; lithium hydroxide; sodium tetrahydroborate; formic acid; (+)-1,2-bis((2S,,5S)-2,5-diethylphospholano)benzene(cyclooctadiene)rhodium(I) trifluoromethanesulfonate; TEA; tetrabutylammomium bromide; hydrogen; tri-n-butyl-tin hydride; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydride; magnesium sulfate; potassium carbonate; Dess-Martin periodane; toluene-4-sulfonic acid; acetic acid; tris-(o-tolyl)phosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium diacetate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; acetonitrile; benzene; 3.1: Jeffery-Heck coupling;

DOI:10.1021/ja050203t

Reference yield:

toluene-4-sulfonic acid 5-iodo-2-methoxy-3-methyl-phenyl ester (351380-16-0) → C40H42N2O7 (851121-91-0)

Guidance literature:

Multi-step reaction with 15 steps

1.1: 90 percent / aq. NaOH / ethane-1,2-diol / 5 h / Heating

2.1: Et₂AlCl / CH₂Cl₂ / 1 h / 20 °C

2.2: 86 percent / CH₂Cl₂ / 24 h / 20 °C

3.1: 85 percent / K₂CO₃ / acetone / 4 h / Heating

4.1: sodium hydride / tetrahydrofuran; dimethylformamide / 0.17 h / 0 °C

4.2: 99 percent / TBAI / tetrahydrofuran; dimethylformamide / 12 h / 20 °C

5.1: 87 percent / TEA; TBABr; (o-tolyl)3P / Pd(OAc)2 / acetonitrile / 12 h / 80 °C

6.1: 93 percent / H₂; Rh[(COD)-(S,S)-Et-DuPhos]⁽¹⁺⁾*TfO^(1-) / CH₂Cl₂; methanol / 72 h / 20 °C / 5171.48 Torr

7.1: 93 percent / aq. LiOH / methanol; tetrahydrofuran / 11 h / 20 °C

8.1: 82 percent / sodium hydride / tetrahydrofuran / 15 h / 20 °C

9.1: BOPCl; TEA / CH₂Cl₂ / 72 h / 20 °C

10.1: DDQ; aq. buffer / CH₂Cl₂ / 0.5 h / 20 °C / pH 7.00

11.1: 84 percent / Dess-Martin periodinane; 2,6-lutidine / CH₂Cl₂ / 12 h / 20 °C

12.1: 59 percent / HCO₂H / 0.2 h / 100 °C

13.1: NaBH₄ / tetrahydrofuran; H₂O / 2 h / 20 °C

14.1: 80 percent / acetic acid; Bu₃SnH; (Ph₃P)2PdCl₂ / CH₂Cl₂ / 0.5 h / 20 °C

15.1: p-TsOH; MgSO₄ / benzene / 4 h / 85 °C

With 2,6-dimethylpyridine; bis-triphenylphosphine-palladium(II) chloride; lithium hydroxide; sodium hydroxide; sodium tetrahydroborate; formic acid; (+)-1,2-bis((2S,,5S)-2,5-diethylphospholano)benzene(cyclooctadiene)rhodium(I) trifluoromethanesulfonate; TEA; tetrabutylammomium bromide; hydrogen; tri-n-butyl-tin hydride; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; diethylaluminium chloride; sodium hydride; magnesium sulfate; potassium carbonate; Dess-Martin periodane; toluene-4-sulfonic acid; acetic acid; tris-(o-tolyl)phosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium diacetate; In tetrahydrofuran; methanol; dichloromethane; water; ethylene glycol; N,N-dimethyl-formamide; acetone; acetonitrile; benzene; 5.1: Jeffery-Heck coupling;

DOI:10.1021/ja050203t

upstream raw materials:

C₄₀H₄₄N₂O₈

C₄₃H₄₆N₂O₈

2-hydroxymethyl-3-iodo-6-methoxy-5-methyl-phenol

toluene-4-sulfonic acid 5-iodo-2-methoxy-3-methyl-phenyl ester

Downstream raw materials:

C₄₆H₅₆N₂O₇Si

C₃₂H₃₀N₂O₈

C₃₂H₃₀N₂O₉

C₃₉H₅₀N₂O₇Si