(2S,3S)-3-(benzoyloxy)-1,4-bis[(diisopropoxyphosphoryl)methoxy]butan-2-yl mesylate

Base Information

• Chemical Name: (2S,3S)-3-(benzoyloxy)-1,4-bis[(diisopropoxyphosphoryl)methoxy]butan-2-yl mesylate
• CAS No.: 959966-53-1
• Molecular Formula: C₂₆H₄₆O₁₃P₂S
• Molecular Weight: 660.657

Synonyms:(2S,3S)-3-(benzoyloxy)-1,4-bis[(diisopropoxyphosphoryl)methoxy]butan-2-yl mesylate

Chemical Property of (2S,3S)-3-(benzoyloxy)-1,4-bis[(diisopropoxyphosphoryl)methoxy]butan-2-yl mesylate

Chemical Property:

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Technology Process of (2S,3S)-3-(benzoyloxy)-1,4-bis[(diisopropoxyphosphoryl)methoxy]butan-2-yl mesylate

There total 1 articles about (2S,3S)-3-(benzoyloxy)-1,4-bis[(diisopropoxyphosphoryl)methoxy]butan-2-yl mesylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(2S,3S)-3-hydroxy-1,4-bis[(diisopropoxyphosphoryl)methoxy]butan-2-yl benzoate (959966-51-9) + methanesulfonyl chloride (124-63-0) → (2S,3S)-3-(benzoyloxy)-1,4-bis[(diisopropoxyphosphoryl)methoxy]butan-2-yl mesylate (959966-53-1)

Guidance literature:

With pyridine; at 0 - 20 ℃;

DOI:10.1016/j.tetasy.2007.09.021

Reference yield: 17.0%

(2S,3S)-3-(benzoyloxy)-1,4-bis[(diisopropoxyphosphoryl)methoxy]butan-2-yl mesylate (959966-53-1) + adenine (66224-66-6,66224-67-7,66224-68-8,66224-69-9,134434-48-3,134434-49-4,134454-76-5,134461-75-9) → 9-{(2R,3R)-3-(benzoyloxy)-1,4-bis[(diisopropoxyphosphoryl)methoxy]butan-2-yl}adenine (959966-60-0)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 110 ℃; for 48h;

DOI:10.1016/j.tetasy.2007.09.021

Reference yield: 15.0%

(2S,3S)-3-(benzoyloxy)-1,4-bis[(diisopropoxyphosphoryl)methoxy]butan-2-yl mesylate (959966-53-1) + 2-Amino-6-chloropurin (10310-21-1) → 2-amino-6-chloro-9-{(2R,3R)-3-(benzoyloxy)-1,4-bis[(diisopropoxyphosphoryl)methoxy]butan-2-yl}purine (959966-58-6)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 110 ℃; for 48h;

DOI:10.1016/j.tetasy.2007.09.021

upstream raw materials:

(2S,3S)-3-hydroxy-1,4-bis[(diisopropoxyphosphoryl)methoxy]butan-2-yl benzoate

methanesulfonyl chloride

Downstream raw materials:

2-amino-6-chloro-9-{(2R,3R)-3-(benzoyloxy)-1,4-bis[(diisopropoxyphosphoryl)methoxy]butan-2-yl}purine

9-{(2R,3R)-3-(benzoyloxy)-1,4-bis[(diisopropoxyphosphoryl)methoxy]butan-2-yl}adenine

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