5-(2-Methoxyphenyl)-2-pyrrolidinone

Base Information

Chemical Name:5-(2-Methoxyphenyl)-2-pyrrolidinone
CAS No.:128100-34-5
Molecular Formula:C₁₁H₁₃NO₂
Molecular Weight:191.23
Hs Code.:
DSSTox Substance ID:DTXSID201293159

Synonyms:5-(2-Methoxyphenyl)-2-pyrrolidinone;128100-34-5;SCHEMBL16796888;DTXSID201293159

Suppliers and Price of 5-(2-Methoxyphenyl)-2-pyrrolidinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(2-Methoxyphenyl)-2-pyrrolidinone

Chemical Property:

XLogP3:1.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:191.094628657
Heavy Atom Count:14
Complexity:217

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=CC=C1C2CCC(=O)N2

Technology Process of 5-(2-Methoxyphenyl)-2-pyrrolidinone

There total 7 articles about 5-(2-Methoxyphenyl)-2-pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 5-(2-methoxyphenyl)-1-(4-methoxyphenyl)pyrrolidin-2-one

: 128100-34-5
5-(2-methoxyphenyl)pyrrolidin-2-one

Guidance literature:: With ammonium cerium (IV) nitrate; In water; acetonitrile; at 5 ℃; for 0.5h;
DOI:10.1016/j.tet.2017.01.013

Reference yield:

: 100-66-3
methoxybenzene

: 149-87-1
Pyroglutamic acid

: 128100-35-6
5-(4-methoxyphenyl)pyrrolidin-2-one

: 128100-34-5
5-(2-methoxyphenyl)pyrrolidin-2-one

Guidance literature:: With methanesulfonic acid; phosphorus pentoxide; In neat (no solvent); at 100 ℃; for 0.5h; Yield given. Yields of byproduct given;
DOI:10.1016/S0040-4039(01)93422-7

Reference yield:

: 58824-49-0
1-(2-methoxyphenyl)prop-2-en-1-ol

: 128100-34-5
5-(2-methoxyphenyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: (3,5-dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']diphenyl-4-en)-dibenzo[b,f]azepine; bis(1,5-cyclooctadiene)diiridium(I) dichloride; aminosulfonic acid; N,N-dimethyl-formamide / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

2: sodium hydrogencarbonate / 3 h / 0 - 20 °C / Inert atmosphere

3: dodecacarbonyl-triangulo-triruthenium; tetra-(n-butyl)ammonium iodide; carbon monoxide / N,N-dimethyl-formamide / 4 h / 150 °C / Autoclave

With (3,5-dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']diphenyl-4-en)-dibenzo[b,f]azepine; bis(1,5-cyclooctadiene)diiridium(I) dichloride; dodecacarbonyl-triangulo-triruthenium; carbon monoxide; aminosulfonic acid; tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate; N,N-dimethyl-formamide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ja4026787