4-(4-Chlorophenyl)-2,3-dihydro-1,3-oxazol-2-one

Base Information

Chemical Name:4-(4-Chlorophenyl)-2,3-dihydro-1,3-oxazol-2-one
CAS No.:36404-33-8
Molecular Formula:C₉H₆ClNO₂
Molecular Weight:244.077
Hs Code.:
European Community (EC) Number:834-634-1

Synonyms:4-(4-chlorophenyl)-2,3-dihydro-1,3-oxazol-2-one;36404-33-8;p-Chlorphenyl-oxazolon;4-(4-chlorophenyl)-3H-1,3-oxazol-2-one;SCHEMBL6604025;CKBZKDNZRNRXGW-UHFFFAOYSA-N;AKOS033458964;4-(4-chlorophenyl)-4-oxazolin-2-one;4-(4-chlorophenyl)-2-oxo-4-oxazoline;EN300-127115;Z1509163669

Suppliers and Price of 4-(4-Chlorophenyl)-2,3-dihydro-1,3-oxazol-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of 4-(4-Chlorophenyl)-2,3-dihydro-1,3-oxazol-2-one

Chemical Property:

XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:195.0087061
Heavy Atom Count:13
Complexity:244

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC=C1C2=COC(=O)N2)Cl

Technology Process of 4-(4-Chlorophenyl)-2,3-dihydro-1,3-oxazol-2-one

There total 3 articles about 4-(4-Chlorophenyl)-2,3-dihydro-1,3-oxazol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.1%

: 36404-33-8
4-(4-chlorophenyl)-4-oxazoline-2-one

Guidance literature:

Reference yield: 36.0%

: 590-28-3
potassium cyanate

: 27993-56-2
1-(4-chlorophenyl)-2-hydroxyethanone

: 36404-33-8
4-(4-chlorophenyl)-4-oxazoline-2-one

Guidance literature:: With acetic acid; In isopropyl alcohol; at 70 ℃; for 3h;
DOI:10.1021/acs.jmedchem.0c01561

Reference yield:

: 99-91-2
para-chloroacetophenone

: 36404-33-8
4-(4-chlorophenyl)-4-oxazoline-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide; [bis(acetoxy)iodo]benzene / methanol / 0 - 20 °C / Inert atmosphere; Schlenk technique

1.2: 20 °C / Inert atmosphere; Schlenk technique

2.1: acetic acid / tetrahydrofuran / 50 °C / Inert atmosphere; Schlenk technique

With [bis(acetoxy)iodo]benzene; acetic acid; potassium hydroxide; In tetrahydrofuran; methanol;
DOI:10.1021/acs.joc.9b01804