27993-56-2

Basic information

• Product Name: 1-(4-CHLOROPHENYL)-2-HYDROXY-1-ETHANONE
• Synonyms: 2-HYDROXY-1-(4-CHLOROPHENYL)ETHANONE;1-(4-CHLOROPHENYL)-2-HYDROXY-1-ETHANONE;4'-CHLORO-2-HYDROXYACETOPHENONE
• CAS NO: 27993-56-2
• Molecular Formula: C₈H₇ClO₂
• Molecular Weight: 170.59
• Mol File: 27993-56-2.mol
• Article Data: 76

Chemical Properties

• Melting Point: 127-129°C
• Boiling Point: 299.9 °C at 760 mmHg
• Flash Point: 135.2 °C
• Appearance: /
• Density: 1.307 g/cm³
• Vapor Pressure: 0.000516mmHg at 25°C
• Refractive Index: 1.568
• Storage Temp.: 2-8°C
• PKA: 12.63±0.10(Predicted)
• CAS DataBase Reference: 1-(4-CHLOROPHENYL)-2-HYDROXY-1-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-CHLOROPHENYL)-2-HYDROXY-1-ETHANONE(27993-56-2)
• EPA Substance Registry System: 1-(4-CHLOROPHENYL)-2-HYDROXY-1-ETHANONE(27993-56-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 27993-56-2(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Synthesis, p. 980, 1988 DOI: 10.1055/s-1988-27774

InChI:InChI=1/C8H7ClO2/c9-7-3-1-6(2-4-7)8(11)5-10/h1-4,10H,5H2

Upstream product

• 53896-48-3 2-iodo-4'-chloroacetophenone 
• 2712-78-9 bis-[(trifluoroacetoxy)iodo]benzene 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 937-20-2 p-chlorophenacyl chloride 
• 60-29-7 diethyl ether 
• 99-91-2 para-chloroacetophenone 
• 30780-43-9 2,2-Dimethoxy-2-(p-chlorophenyl)-ethanol 
• 179811-64-4 4-(aminomethyl)benzene-1,2-diol hydrochloride 
• 184849-67-0 1-(4-chlorophenyl)ethanone O-acetyl oxime 
• 873-73-4 4-n-chlorophenylacetylene 
• 104-88-1 4-chlorobenzaldehyde 
• 298-12-4 Glyoxilic acid 
• 67-56-1 methanol 
• 58518-76-6 ((1-(4-chlorophenyl)vinyl)oxy)trimethylsilane 

Downstream Products

• 35730-25-7 1-(4-bromo-phenyl)-1-(4-chloro-phenyl)-ethane-1,2-diol 
• 61883-64-5 butyl-[4-(4-chloro-phenyl)-oxazol-2-yl]-amine 
• 123365-20-8 1-(4-Chloro-phenyl)-2-methoxymethoxy-ethanone 
• 74-11-3 para-chlorobenzoic acid 
• 50-00-0 formaldehyd 
• 7477-64-7 (S)-1-(4-chlorophenyl)-1,2-ethanediol 
• 871024-63-4 1-(4-chlorophenyl)-2-hydroxy-3-(N-diphenylphosphinoylamino)-3-phenylpropan-1-one 
• 152142-03-5 (1R)-1-(4-chlorophenyl)-1,2-ethanediol 
• 17286-63-4 2-(4-chlorophenyl)quinoxaline 
• 1380583-43-6 C₁₉H₁₇ClN₂O₂ 
• 1380583-38-9 C₁₇H₁₅ClN₂O 
• 67483-73-2 benzyl p-chlorobenzoate 
• 19048-85-2 (4'-chlorobenzyl) 4-chlorobenzoate 
• 1078-32-6 2-chloroethyl 4-chlorobenzoate 

Relevant articles and documents

DIRECT α-HYDROXYLATION OF KETONES USING IODOSOBENZENE

Ketones are converted smoothly into the corresponding acyloin with a high degree of selectivity upon treatment with iodosobenzene or phenyl-iodosodiacetate in methanolic sodium hydroxyde.

Preparation and Application of α-Imino Ketones through One-Pot Tandem Reactions Based on Heyns Rearrangement

α-Imino ketone is a useful building block for the preparation of α-amino ketones and α-amino alcohols. However, its preparation has been seldomly seen. Herein, a metal-free and operationally simple strategy has been developed to generate α-imino ketones with high regioselectivity. Meanwhile, the method allowed for the preparation of various N,O-ketals with high regioselectivities and diastereoselectivities through cascade reactions in one pot.

Palladium-Catalyzed (3+3) Annulation of Allenylethylene Carbonates with Nitrile Oxides

In this paper, we designed and synthesized a new type of cyclic carbonates, allenylethylene carbonates (AECs). With AECs as reactive precursors, we developed palladium-catalyzed (3+3) annulation of AECs with nitrile oxides. Various AECs worked well in this reaction under mild reaction conditions. A variety of 5,6-dihydro-1,4,2-dioxazine derivatives with allenyl quaternary stereocenters can be accessed in a facile manner in high yields (≤98%).

Aerobic Direct Dioxygenation of Terminal/Internal Alkynes to α-Hydroxyketones by an Fe Porphyrin Catalyst

We herein report a new synthetic method for the preparation of α-hydroxyketones by the dioxygenation of alkynes. The reaction proceeds at room temperature under the action of Fe porphyrin and pinacolborane under air as a green oxidant to produce α-hydroxyketones. The mild reaction conditions allow chemoselective oxidation with functional group tolerance. Terminal alkynes in addition to internal alkynes are applicable, affording unsymmetrical α-hydroxyketones that are difficult to obtain by any reported dioxygenation of unsaturated C?C bonds.