[4-(4-methyl-benzyl)-piperidin-1-yl]-oxo-acetic acid ethyl ester

Base Information

• Chemical Name: [4-(4-methyl-benzyl)-piperidin-1-yl]-oxo-acetic acid ethyl ester
• CAS No.: 496056-39-4
• Molecular Formula: C₁₇H₂₃NO₃
• Molecular Weight: 289.375
• Mol file: 496056-39-4.mol

Synonyms:[4-(4-methyl-benzyl)-piperidin-1-yl]-oxo-acetic acid ethyl ester

Chemical Property of [4-(4-methyl-benzyl)-piperidin-1-yl]-oxo-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [4-(4-methyl-benzyl)-piperidin-1-yl]-oxo-acetic acid ethyl ester

There total 1 articles about [4-(4-methyl-benzyl)-piperidin-1-yl]-oxo-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Ethyl oxalyl chloride (4755-77-5) + 4-[(4methylphenyl)methyl]piperidine (92822-01-0) → [4-(4-methyl-benzyl)-piperidin-1-yl]-oxo-acetic acid ethyl ester (496056-39-4)

Guidance literature:

With TEA; In chloroform; at 10 ℃; for 2h;

DOI:10.1016/j.bmcl.2004.05.053

Reference yield:

[4-(4-methyl-benzyl)-piperidin-1-yl]-oxo-acetic acid ethyl ester (496056-39-4) → [4-(4-methyl-benzyl)-piperidin-1-yl]-oxo-acetic acid (496056-40-7)

Guidance literature:

With potassium hydroxide; In ethanol; at 20 ℃; for 2h;

DOI:10.1016/j.bmcl.2004.05.053

Reference yield:

[4-(4-methyl-benzyl)-piperidin-1-yl]-oxo-acetic acid ethyl ester (496056-39-4) → N-(1H-indol-5-yl)-2-{4-[(4-methylphenyl)methyl]piperidin-1-yl}-2-oxoacetamide

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydroxide; water / ethanol / 0 - 20 °C

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide; water / 0.25 h / Inert atmosphere

2.2: 24 h / 20 °C / Inert atmosphere

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2021.113560

upstream raw materials:

Ethyl oxalyl chloride

4-[(4methylphenyl)methyl]piperidine

Downstream raw materials:

[4-(4-methyl-benzyl)-piperidin-1-yl]-oxo-acetic acid