(R)-5-(2-(tert-butyldimethylsilyloxy)propylamino)-2-methoxybenzonitrile

Base Information

Chemical Name:(R)-5-(2-(tert-butyldimethylsilyloxy)propylamino)-2-methoxybenzonitrile
CAS No.:1338327-52-8
Molecular Formula:C₁₇H₂₈N₂O₂Si
Molecular Weight:320.507
Hs Code.:

Synonyms:(R)-5-(2-(tert-butyldimethylsilyloxy)propylamino)-2-methoxybenzonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-5-(2-(tert-butyldimethylsilyloxy)propylamino)-2-methoxybenzonitrile

Chemical Property:

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Technology Process of (R)-5-(2-(tert-butyldimethylsilyloxy)propylamino)-2-methoxybenzonitrile

There total 2 articles about (R)-5-(2-(tert-butyldimethylsilyloxy)propylamino)-2-methoxybenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.6%

: 955135-14-5
(R)-2-((tert-butyldimethylsilyl)oxy)propan-1-amine

: 144649-99-0
5-bromo-2-methoxybenzonitrile

: 1338327-52-8
(R)-5-(2-(tert-butyldimethylsilyloxy)propylamino)-2-methoxybenzonitrile

Guidance literature:: With caesium carbonate; palladium diacetate; XPhos; In toluene; at 120 ℃; for 50h; Inert atmosphere;

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1338327-52-8
(R)-5-(2-(tert-butyldimethylsilyloxy)propylamino)-2-methoxybenzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: caesium carbonate / palladium diacetate; XPhos / toluene / 50 h / 120 °C / Inert atmosphere

With caesium carbonate; triethylamine; palladium diacetate; XPhos; In dichloromethane; toluene;