3-benzyloxy-4-fluorobenzyl bromide

Base Information

• Chemical Name: 3-benzyloxy-4-fluorobenzyl bromide
• CAS No.: 123926-57-8
• Molecular Formula: C₁₄H₁₂BrFO
• Molecular Weight: 295.151
• Mol file: 123926-57-8.mol

Synonyms:3-benzyloxy-4-fluorobenzyl bromide

Chemical Property of 3-benzyloxy-4-fluorobenzyl bromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-benzyloxy-4-fluorobenzyl bromide

There total 3 articles about 3-benzyloxy-4-fluorobenzyl bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

3-benzyloxy-4-fluorobenzyl alcohol (959251-11-7) → 3-benzyloxy-4-fluorobenzyl bromide (123926-57-8)

Guidance literature:

With phosphorus tribromide; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmcl.2013.01.106

Reference yield:

3-benzyloxy-4-fluorobenzaldehyde (103438-91-1) → 3-benzyloxy-4-fluorobenzyl bromide (123926-57-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

2: phosphorus tribromide / dichloromethane / 20 °C

With sodium tetrahydroborate; phosphorus tribromide; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2013.01.106

Reference yield:

→ 3-benzyloxy-4-fluorobenzyl bromide (123926-57-8) + 3-benzyloxy-4-fluorobenzaldehyde (103438-91-1)

Guidance literature:

upstream raw materials:

3-benzyloxy-4-fluorobenzaldehyde

3-benzyloxy-4-fluorobenzyl alcohol

Downstream raw materials:

C₁₅H₁₂FNO

C₁₅H₁₆FNO

2-(4-fluoro-3-hydroxyphenyl)ethylamine hydrobromide

C₁₉H₂₈FN₃O₅