2-(4-fluoro-3-hydroxyphenyl)ethylamine hydrobromide

Base Information

Chemical Name:2-(4-fluoro-3-hydroxyphenyl)ethylamine hydrobromide
CAS No.:128495-64-7
Molecular Formula:BrH*C₈H₁₀FNO
Molecular Weight:236.084
Hs Code.:

Synonyms:2-(4-fluoro-3-hydroxyphenyl)ethylamine hydrobromide

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Chemical Property of 2-(4-fluoro-3-hydroxyphenyl)ethylamine hydrobromide

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Technology Process of 2-(4-fluoro-3-hydroxyphenyl)ethylamine hydrobromide

There total 13 articles about 2-(4-fluoro-3-hydroxyphenyl)ethylamine hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1426298-31-8
C₁₅H₁₆FNO

: 128495-64-7
2-(4-fluoro-3-hydroxyphenyl)ethylamine hydrobromide

Guidance literature:: With hydrogen bromide; In water; at 130 ℃; for 6h; Inert atmosphere;
DOI:10.1016/j.bmcl.2013.01.106

Reference yield: 92.0%

: 128495-48-7
2-(4-fluoro-3-methoxyphenyl)ethan-1-amine

: 128495-64-7
2-(4-fluoro-3-hydroxyphenyl)ethylamine hydrobromide

Guidance literature:: With hydrogen bromide; In water; for 3h; Reflux;
DOI:10.1039/c7cc08024g

Reference yield:

: 128495-46-5
4-fluoro-3-methoxybenzaldehyde

: 128495-64-7
2-(4-fluoro-3-hydroxyphenyl)ethylamine hydrobromide

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / Na₂CO₃, methylamine hydrochloride / ethanol / 72 h / Ambient temperature

2: 54 percent / LiAlH₄ / tetrahydrofuran / 12 h / Ambient temperature

3: 63 percent / 48percent HBr / 3 h / 125 - 130 °C

With lithium aluminium tetrahydride; hydrogen bromide; methylamine hydrochloride; sodium carbonate; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00171a014