[2-({methyl-[1-(S)-phenyl-2-pyrrolidin-1-yl-ethyl]-carbamoyl}-methyl)-benzyl]-carbamic acid tert-butyl ester

Base Information

• Chemical Name: [2-({methyl-[1-(S)-phenyl-2-pyrrolidin-1-yl-ethyl]-carbamoyl}-methyl)-benzyl]-carbamic acid tert-butyl ester
• CAS No.: 808752-99-0
• Molecular Formula: C₂₇H₃₇N₃O₃
• Molecular Weight: 451.609
• Mol file: 808752-99-0.mol

Synonyms:[2-({methyl-[1-(S)-phenyl-2-pyrrolidin-1-yl-ethyl]-carbamoyl}-methyl)-benzyl]-carbamic acid tert-butyl ester

Chemical Property of [2-({methyl-[1-(S)-phenyl-2-pyrrolidin-1-yl-ethyl]-carbamoyl}-methyl)-benzyl]-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2-({methyl-[1-(S)-phenyl-2-pyrrolidin-1-yl-ethyl]-carbamoyl}-methyl)-benzyl]-carbamic acid tert-butyl ester

There total 5 articles about [2-({methyl-[1-(S)-phenyl-2-pyrrolidin-1-yl-ethyl]-carbamoyl}-methyl)-benzyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2-(tert-butoxycarbonylaminomethyl)phenylacetic acid (40851-66-9) + (1S)-N-methyl-1-phenyl-2-(pyrrolidin-1-yl)ethanamine (116508-51-1) → [2-({methyl-[1-(S)-phenyl-2-pyrrolidin-1-yl-ethyl]-carbamoyl}-methyl)-benzyl]-carbamic acid tert-butyl ester (808752-99-0)

Guidance literature:

O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 0 - 20 ℃;

Reference yield:

ortho-bromophenylacetic acid (18698-97-0) → [2-({methyl-[1-(S)-phenyl-2-pyrrolidin-1-yl-ethyl]-carbamoyl}-methyl)-benzyl]-carbamic acid tert-butyl ester (808752-99-0)

Guidance literature:

Multi-step reaction with 6 steps

1: H₂SO₄ / Heating

2: dimethylformamide / Heating

3: H₂; aq. HCl / Pd/C / methanol / 25 °C / 3620.04 Torr

4: Et₃N / tetrahydrofuran / 25 °C

5: aq. LiOH / tetrahydrofuran / 25 °C

6: O-benzotriazol-1-yl-N,N,N',N'-tetramethyluronium*BF₄; (iPr)2EtN / acetonitrile / 25 °C

With hydrogenchloride; lithium hydroxide; sulfuric acid; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.bmcl.2005.03.020

Reference yield:

methyl 2-(2-bromophenyl)acetate (57486-69-8) → [2-({methyl-[1-(S)-phenyl-2-pyrrolidin-1-yl-ethyl]-carbamoyl}-methyl)-benzyl]-carbamic acid tert-butyl ester (808752-99-0)

Guidance literature:

Multi-step reaction with 5 steps

1: dimethylformamide / Heating

2: H₂; aq. HCl / Pd/C / methanol / 25 °C / 3620.04 Torr

3: Et₃N / tetrahydrofuran / 25 °C

4: aq. LiOH / tetrahydrofuran / 25 °C

5: O-benzotriazol-1-yl-N,N,N',N'-tetramethyluronium*BF₄; (iPr)2EtN / acetonitrile / 25 °C

With hydrogenchloride; lithium hydroxide; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.bmcl.2005.03.020

upstream raw materials:

2-(tert-butoxycarbonylaminomethyl)phenylacetic acid

(1S)-N-methyl-1-phenyl-2-(pyrrolidin-1-yl)ethanamine

ortho-bromophenylacetic acid

methyl 2-(2-bromophenyl)acetate

Downstream raw materials:

2-(2-aminomethyl-phenyl)-N-methyl-N-(1-phenyl-2-pyrrolidin-1-yl-ethyl)-acetamide