(S)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N,2-dimethyl-3-phenylpropanamide

Base Information

Chemical Name:(S)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N,2-dimethyl-3-phenylpropanamide
CAS No.:159345-08-1
Molecular Formula:C₂₀H₂₅NO₂
Molecular Weight:311.424
Hs Code.:

Synonyms:(S)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N,2-dimethyl-3-phenylpropanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N,2-dimethyl-3-phenylpropanamide

Chemical Property:

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Technology Process of (S)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N,2-dimethyl-3-phenylpropanamide

There total 3 articles about (S)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N,2-dimethyl-3-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 14980-86-0,42407-58-9
N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N-methyl-3-phenylpropanamide

: 74-88-4
methyl iodide

: 159345-08-1,352530-53-1
(S)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N,2-dimethyl-3-phenylpropanamide

Guidance literature:: With n-butyllithium; diisopropylamine; lithium chloride; In tetrahydrofuran; hexane; at -78 ℃;
DOI:10.1021/ja970402f

Reference yield:

: 90-82-4,7009-81-6,90-83-5,6912-63-6
pseudoephedrine

: 159345-08-1,352530-53-1
(S)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N,2-dimethyl-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / Et₃N / tetrahydrofuran / 0.17 h

2: 95 percent / LiCl, diisopropylamine, n-BuLi / tetrahydrofuran; hexane / -78 °C

With n-butyllithium; triethylamine; diisopropylamine; lithium chloride; In tetrahydrofuran; hexane;
DOI:10.1021/ja970402f

Reference yield:

: 645-45-4
hydrocinnamic acid chloride

: 159345-08-1,352530-53-1
(S)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N,2-dimethyl-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / Et₃N / tetrahydrofuran / 0.17 h

2: 95 percent / LiCl, diisopropylamine, n-BuLi / tetrahydrofuran; hexane / -78 °C

With n-butyllithium; triethylamine; diisopropylamine; lithium chloride; In tetrahydrofuran; hexane;
DOI:10.1021/ja970402f