5-[(benzyloxy)methyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

Base Information

Chemical Name:5-[(benzyloxy)methyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine
CAS No.:304849-80-7
Molecular Formula:C₂₉H₄₆N₂O₈Si₂
Molecular Weight:606.864
Hs Code.:

Synonyms:5-[(benzyloxy)methyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

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Chemical Property of 5-[(benzyloxy)methyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

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Technology Process of 5-[(benzyloxy)methyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

There total 4 articles about 5-[(benzyloxy)methyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 69304-37-6
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

: 24751-66-4
5-[(benzyloxy)methyl]uridine

: 304849-80-7
5-[(benzyloxy)methyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

Guidance literature:: In pyridine; at 20 ℃; for 18h;
DOI:10.1002/1522-2675(20000809)83:8<1962::AID-HLCA1962>3.0.CO;2-8

Reference yield:

: 13111-67-6
2',3',5'-tri-O-acetyl-5-[(benzyloxy)methyl]uridine

: 304849-80-7
5-[(benzyloxy)methyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / 2M NaOH / H₂O; tetrahydrofuran; methanol / 0.58 h / 0 °C

2: 78 percent / pyridine / 18 h / 20 °C

With sodium hydroxide; In tetrahydrofuran; pyridine; methanol; water; 1: Hydrolysis / 2: Substitution;
DOI:10.1002/1522-2675(20000809)83:8<1962::AID-HLCA1962>3.0.CO;2-8

Reference yield:

: 7295-02-5
benzyl hydroxymethyl uridine

: 304849-80-7
5-[(benzyloxy)methyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

Guidance literature:: Multi-step reaction with 3 steps

1: 74 percent / N,O-bis(trimethylsilyl)acetamide; CF₃SO₃SiMe₃ / acetonitrile / 18 h / 20 °C

2: 95 percent / 2M NaOH / H₂O; tetrahydrofuran; methanol / 0.58 h / 0 °C

3: 78 percent / pyridine / 18 h / 20 °C

With sodium hydroxide; N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate; In tetrahydrofuran; pyridine; methanol; water; acetonitrile; 1: Substitution / 2: Hydrolysis / 3: Substitution;
DOI:10.1002/1522-2675(20000809)83:8<1962::AID-HLCA1962>3.0.CO;2-8