3,3,6,6-tetramethyl-9-[2-(prop-2-yn-1-yloxy)phenyl]-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione

Base Information

Chemical Name:3,3,6,6-tetramethyl-9-[2-(prop-2-yn-1-yloxy)phenyl]-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione
CAS No.:1365618-41-2
Molecular Formula:C₂₆H₂₈O₄
Molecular Weight:404.506
Hs Code.:

Synonyms:3,3,6,6-tetramethyl-9-[2-(prop-2-yn-1-yloxy)phenyl]-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione

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Chemical Property of 3,3,6,6-tetramethyl-9-[2-(prop-2-yn-1-yloxy)phenyl]-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione

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Technology Process of 3,3,6,6-tetramethyl-9-[2-(prop-2-yn-1-yloxy)phenyl]-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione

There total 2 articles about 3,3,6,6-tetramethyl-9-[2-(prop-2-yn-1-yloxy)phenyl]-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 6469-54-1
9-(2-hydroxyphenyl)-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione

: 106-96-7
propargyl bromide

: 1365618-41-2
3,3,6,6-tetramethyl-9-[2-(prop-2-yn-1-yloxy)phenyl]-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; toluene; at 25 ℃; for 16h; Inert atmosphere;
DOI:10.1016/j.bmcl.2012.01.126

Reference yield:

: 90-02-8
salicylaldehyde

: 1365618-41-2
3,3,6,6-tetramethyl-9-[2-(prop-2-yn-1-yloxy)phenyl]-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1: iodine / isopropyl alcohol / 0.27 h / 100 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide; toluene / 16 h / 25 °C / Inert atmosphere

With iodine; potassium carbonate; In N,N-dimethyl-formamide; isopropyl alcohol; toluene;
DOI:10.1016/j.bmcl.2012.01.126

Reference yield: 98.0%

: 1365618-41-2
3,3,6,6-tetramethyl-9-[2-(prop-2-yn-1-yloxy)phenyl]-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione

: 622-37-7
Phenyl azide

: 3,3,6,6-tetramethyl-9-{2-[(1-phenyl-1H-1,2,3-triazol-4-yl)methoxy]phenyl}-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione

Guidance literature:: With copper(l) iodide; In acetonitrile; at 20 ℃; for 0.5h; Reagent/catalyst; Solvent; Catalytic behavior;
DOI:10.1134/S1070363217090171