(4-(4-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)phenylethynyl)phenyl)methylamine

Base Information

Chemical Name:(4-(4-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)phenylethynyl)phenyl)methylamine
CAS No.:937701-36-5
Molecular Formula:C₂₁H₂₄FNO₃
Molecular Weight:357.425
Hs Code.:

Synonyms:(4-(4-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)phenylethynyl)phenyl)methylamine

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Chemical Property of (4-(4-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)phenylethynyl)phenyl)methylamine

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Technology Process of (4-(4-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)phenylethynyl)phenyl)methylamine

There total 5 articles about (4-(4-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)phenylethynyl)phenyl)methylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 937701-34-3
4-((4-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)phenyl)ethynyl)aniline

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 937701-36-5
(4-(4-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)phenylethynyl)phenyl)methylamine

Guidance literature:: 4-((4-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)phenyl)ethynyl)aniline; formaldehyd; With sodium methylate; In methanol; at 72 ℃; for 3h; Inert atmosphere;

With sodium tetrahydroborate; In methanol; at 0 ℃; Reflux; Inert atmosphere;
DOI:10.1021/ol8029593

Reference yield:

: 937701-59-2
1-{2-[2-(2-fluoroethoxy)ethoxy]ethoxy}-4-iodobenzene

: 937701-36-5
(4-(4-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)phenylethynyl)phenyl)methylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 72 percent / aq. NH₃ / PdCl₂(PPh₃)2; CuI / tetrahydrofuran / 4 h / 20 °C

2.1: NaOMe / methanol / 2 h / Heating

2.2: 90 percent / NaBH₄ / methanol / 1 h / Heating

With ammonium hydroxide; sodium methylate; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; methanol; 1.1: Sonogashira reaction;
DOI:10.1021/jm070090j

Reference yield:

: 937701-64-9
1-chloro-2-[2-(2-fluoroethoxy)ethoxy]ethane

: 937701-36-5
(4-(4-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)phenylethynyl)phenyl)methylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 72 percent / NaI; Cs₂CO₃ / dimethylformamide / 16 h / 110 °C

2.1: 72 percent / aq. NH₃ / PdCl₂(PPh₃)2; CuI / tetrahydrofuran / 4 h / 20 °C

3.1: NaOMe / methanol / 2 h / Heating

3.2: 90 percent / NaBH₄ / methanol / 1 h / Heating

With ammonium hydroxide; sodium methylate; caesium carbonate; sodium iodide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 2.1: Sonogashira reaction;
DOI:10.1021/jm070090j