937701-59-2Relevant academic research and scientific papers
PHEN-NAPHTHALENE AND PHEN-QUINOLINE DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES
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, (2008/12/04)
This invention relates to methods of imaging amyloid deposits, radiolabeled compounds, and methods of making radiolabeled compounds useful in imaging amyloid deposits. This invention also relates to compounds and methods of making compounds for inhibiting the aggregation of amyloid proteins to form amyloid deposits and methods of delivering therapeutic agents to amyloid deposits.
Quick assembly of 1,4-diphenyltriazoles as probes targeting β-amyloid aggregates in Alzheimer's disease
Qu, Wenchao,Kung, Mei-Ping,Hou, Catherine,Oya, Shunichi,Kung, Hank F.
, p. 3380 - 3387 (2008/02/08)
Accumulation of β-amyloid aggregates (Aβ) in the brain is linked to the pathogenesis of Alzheimer's disease (AD). We report a novel approach for producing 1,4-diphenyltriazoles as probes for targeting Aβ aggregates in the brain. The imaging probes, a seri
New diphenylacetylenes as probes for positron emission tomographic imaging of amyloid plaques
Chandra, Rajesh,Oya, Shunichi,Kung, Mei-Ping,Hou, Catherine,Jin, Lee-Way,Kung, Hank F.
, p. 2415 - 2423 (2008/02/05)
A series of 18F fluoropegylated diphenylacetylenes as probes for binding to Aβ plaques were successfully prepared. These relatively rigid acetylenes, 12a, 12b, 14a, and 14b, displayed high binding affinities in postmortem AD brain homogenates (
