(3-{4-[5-(5-benzyloxy-1H-indol-2-yl)pyridin-3-yl]phenoxy}propyl)dimethylamine

Base Information

• Chemical Name: (3-{4-[5-(5-benzyloxy-1H-indol-2-yl)pyridin-3-yl]phenoxy}propyl)dimethylamine
• CAS No.: 1037552-44-5
• Molecular Formula: C₃₁H₃₁N₃O₂
• Molecular Weight: 477.606

Synonyms:(3-{4-[5-(5-benzyloxy-1H-indol-2-yl)pyridin-3-yl]phenoxy}propyl)dimethylamine

Chemical Property of (3-{4-[5-(5-benzyloxy-1H-indol-2-yl)pyridin-3-yl]phenoxy}propyl)dimethylamine

Chemical Property:

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Technology Process of (3-{4-[5-(5-benzyloxy-1H-indol-2-yl)pyridin-3-yl]phenoxy}propyl)dimethylamine

There total 1 articles about (3-{4-[5-(5-benzyloxy-1H-indol-2-yl)pyridin-3-yl]phenoxy}propyl)dimethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(3-{4-[5-(1-phenylsulfonyl-5-benzyloxy-1H-indol-2-yl)pyridin-3-yl]phenoxy}propyl)dimethylamine (1037552-36-5) → (3-{4-[5-(5-benzyloxy-1H-indol-2-yl)pyridin-3-yl]phenoxy}propyl)dimethylamine (1037552-44-5)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 3h; Heating;

DOI:10.1016/j.bmc.2008.03.034

Reference yield: 70.0%

(3-{4-[5-(5-benzyloxy-1H-indol-2-yl)pyridin-3-yl]phenoxy}propyl)dimethylamine (1037552-44-5) + (2-chloroethyl)dimethylamine hydrochloride (4584-46-7) → [3-(4-{5-[5-benzyloxy-1-(2-(dimethylamino)ethyl)-1H-indol-2-yl]pyridin-3-yl}phenoxy)propyl]dimethylamine (1037552-63-8)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 100 ℃; for 2h;

DOI:10.1016/j.bmc.2008.03.034

Reference yield: 67.0%

(3-{4-[5-(5-benzyloxy-1H-indol-2-yl)pyridin-3-yl]phenoxy}propyl)dimethylamine (1037552-44-5) + 3-(dimethylamino)propyl chloride hydrochloride (5407-04-5) → [3-(4-{5-[5-benzyloxy-1-(3-(dimethylamino)propyl)-1H-indol-2-yl]pyridin-3-yl}phenoxy)propyl]dimethylamine

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 100 ℃; for 2h;

DOI:10.1016/j.bmc.2008.03.034

upstream raw materials:

(3-{4-[5-(1-phenylsulfonyl-5-benzyloxy-1H-indol-2-yl)pyridin-3-yl]phenoxy}propyl)dimethylamine

Downstream raw materials:

C₂₄H₂₅N₃O₂

[3-(4-{5-[5-benzyloxy-1-(2-(dimethylamino)ethyl)-1H-indol-2-yl]pyridin-3-yl}phenoxy)propyl]dimethylamine

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