N-{3-[2-(4-fluorophenoxy)ethyl]-2,4-dioxo-1,3-diazaspiro[4.5]dec-8-yl}-2-cyanobenzene sulfonamide

Base Information

Chemical Name:N-{3-[2-(4-fluorophenoxy)ethyl]-2,4-dioxo-1,3-diazaspiro[4.5]dec-8-yl}-2-cyanobenzene sulfonamide
CAS No.:1404059-72-8
Molecular Formula:C₂₃H₂₃FN₄O₅S
Molecular Weight:486.524
Hs Code.:

Synonyms:N-{3-[2-(4-fluorophenoxy)ethyl]-2,4-dioxo-1,3-diazaspiro[4.5]dec-8-yl}-2-cyanobenzene sulfonamide

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Chemical Property of N-{3-[2-(4-fluorophenoxy)ethyl]-2,4-dioxo-1,3-diazaspiro[4.5]dec-8-yl}-2-cyanobenzene sulfonamide

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Technology Process of N-{3-[2-(4-fluorophenoxy)ethyl]-2,4-dioxo-1,3-diazaspiro[4.5]dec-8-yl}-2-cyanobenzene sulfonamide

There total 6 articles about N-{3-[2-(4-fluorophenoxy)ethyl]-2,4-dioxo-1,3-diazaspiro[4.5]dec-8-yl}-2-cyanobenzene sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1404059-57-9
8-amino-3-[2-(4-fluorophenoxy)ethyl]-1,3-diazaspiro[4.5]decane-2,4-dione

: 69360-26-5
2-cyanobenzenesulfonyl chloride

: 1404059-72-8
N-{3-[2-(4-fluorophenoxy)ethyl]-2,4-dioxo-1,3-diazaspiro[4.5]dec-8-yl}-2-cyanobenzene sulfonamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1007/s00044-012-0265-x

Reference yield:

: 1404059-56-8
tert-butyl {3-[2-(4-fluorophenoxy)ethyl]-2,4-dioxo-1,3-diazaspiro[4.5]dec-8-yl}carbamate

: 1404059-72-8
N-{3-[2-(4-fluorophenoxy)ethyl]-2,4-dioxo-1,3-diazaspiro[4.5]dec-8-yl}-2-cyanobenzene sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane / 4 h / 0 - 20 °C

2: triethylamine / dichloromethane / 16 h / 20 °C

With hydrogenchloride; triethylamine; In 1,4-dioxane; dichloromethane;
DOI:10.1007/s00044-012-0265-x

Reference yield:

: 224309-64-2
tert-butyl N-(4-hydroxycyclohexyl)carbamate

: 1404059-72-8
N-{3-[2-(4-fluorophenoxy)ethyl]-2,4-dioxo-1,3-diazaspiro[4.5]dec-8-yl}-2-cyanobenzene sulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 2 h / -78 °C

2: sodium cyanide / ethanol; water / 48 h / -78 - 50 °C

3: potassium carbonate / acetonitrile / 6 h / Reflux

4: hydrogenchloride / 1,4-dioxane / 4 h / 0 - 20 °C

5: triethylamine / dichloromethane / 16 h / 20 °C

With hydrogenchloride; sodium cyanide; oxalyl dichloride; potassium carbonate; dimethyl sulfoxide; triethylamine; In 1,4-dioxane; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1007/s00044-012-0265-x