di-tert-butyl 3-(3-tert-butyl-5-{[(2-fluoro-4-{[2-(methylcarbamoyl)pyridin-4-yl]oxy}phenyl)carbamoyl]amino}-1H-pyrazol-1-yl)benzyl phosphate

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Chemical Name:di-tert-butyl 3-(3-tert-butyl-5-{[(2-fluoro-4-{[2-(methylcarbamoyl)pyridin-4-yl]oxy}phenyl)carbamoyl]amino}-1H-pyrazol-1-yl)benzyl phosphate
CAS No.:1036712-88-5
Molecular Formula:C₃₆H₄₆FN₆O₇P
Molecular Weight:724.769
Hs Code.:

Synonyms:di-tert-butyl 3-(3-tert-butyl-5-{[(2-fluoro-4-{[2-(methylcarbamoyl)pyridin-4-yl]oxy}phenyl)carbamoyl]amino}-1H-pyrazol-1-yl)benzyl phosphate

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Chemical Property of di-tert-butyl 3-(3-tert-butyl-5-{[(2-fluoro-4-{[2-(methylcarbamoyl)pyridin-4-yl]oxy}phenyl)carbamoyl]amino}-1H-pyrazol-1-yl)benzyl phosphate

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Technology Process of di-tert-butyl 3-(3-tert-butyl-5-{[(2-fluoro-4-{[2-(methylcarbamoyl)pyridin-4-yl]oxy}phenyl)carbamoyl]amino}-1H-pyrazol-1-yl)benzyl phosphate

There total 6 articles about di-tert-butyl 3-(3-tert-butyl-5-{[(2-fluoro-4-{[2-(methylcarbamoyl)pyridin-4-yl]oxy}phenyl)carbamoyl]amino}-1H-pyrazol-1-yl)benzyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1036712-77-2
4-{4-[({3-tert-butyl-1-[3-(hydroxymethyl)phenyl]-1H-pyrazol-5-yl}carbamoyl)amino]-3-fluorophenoxy}-N-methylpyridine-2-carboxamide

: 117924-33-1
di-tert-butyl N,N-diethylphosphoramidite

: 1036712-88-5
di-tert-butyl 3-(3-tert-butyl-5-{[(2-fluoro-4-{[2-(methylcarbamoyl)pyridin-4-yl]oxy}phenyl)carbamoyl]amino}-1H-pyrazol-1-yl)benzyl phosphate

Guidance literature:: 4-{4-[({3-tert-butyl-1-[3-(hydroxymethyl)phenyl]-1H-pyrazol-5-yl}carbamoyl)amino]-3-fluorophenoxy}-N-methylpyridine-2-carboxamide; di-tert-butyl N,N-diethylphosphoramidite; With 1H-tetrazole; In tetrahydrofuran; at 20 ℃; for 2h;

With 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; at -40 - 20 ℃; for 0.166667h;

With water; sodium hydrogencarbonate; In ethyl acetate;

Reference yield:

: 725685-92-7
3-(5-amino-3-tert-butyl-pyrazol-1-yl)-benzoic acid ethyl ester

: 1036712-88-5
di-tert-butyl 3-(3-tert-butyl-5-{[(2-fluoro-4-{[2-(methylcarbamoyl)pyridin-4-yl]oxy}phenyl)carbamoyl]amino}-1H-pyrazol-1-yl)benzyl phosphate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / tetrahydrofuran / 20 °C

2.1: triethylamine / tetrahydrofuran / 20 °C

3.1: sodium tetrahydroborate / ethanol / 20 °C

4.1: 1H-tetrazole / tetrahydrofuran / 2 h / 20 °C

4.2: 0.17 h / -40 - 20 °C

With 1H-tetrazole; sodium tetrahydroborate; potassium carbonate; triethylamine; In tetrahydrofuran; ethanol;

Reference yield:

: 59997-51-2
trimethylacetylacetonitrile

: 1036712-88-5
di-tert-butyl 3-(3-tert-butyl-5-{[(2-fluoro-4-{[2-(methylcarbamoyl)pyridin-4-yl]oxy}phenyl)carbamoyl]amino}-1H-pyrazol-1-yl)benzyl phosphate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / 18 h / 90 °C

2.1: potassium carbonate / tetrahydrofuran / 20 °C

3.1: triethylamine / tetrahydrofuran / 20 °C

4.1: sodium tetrahydroborate / ethanol / 20 °C

5.1: 1H-tetrazole / tetrahydrofuran / 2 h / 20 °C

5.2: 0.17 h / -40 - 20 °C

With 1H-tetrazole; sodium tetrahydroborate; sulfuric acid; potassium carbonate; triethylamine; In tetrahydrofuran; ethanol;