6-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyridazine-3-carboxylic acid

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Chemical Name:6-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyridazine-3-carboxylic acid
CAS No.:1374673-07-0
Molecular Formula:C₁₅H₁₂FN₅O₃
Molecular Weight:329.29
Hs Code.:

Synonyms:6-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyridazine-3-carboxylic acid

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Chemical Property of 6-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyridazine-3-carboxylic acid

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Technology Process of 6-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyridazine-3-carboxylic acid

There total 12 articles about 6-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyridazine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1374672-35-1
6-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyridazine-3-carboxylic acid ethyl ester

: 1374673-07-0
6-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyridazine-3-carboxylic acid

Guidance literature:: 6-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyridazine-3-carboxylic acid ethyl ester; With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 20 ℃; for 16h;

With hydrogenchloride; In water;

Reference yield:

: 1374673-05-8
3-chloro-6-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyridazine

: 1374673-07-0
6-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyridazine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / Inert atmosphere

2: water; lithium hydroxide monohydrate / tetrahydrofuran / 16 h / 20 °C

With lithium hydroxide monohydrate; water; sodium carbonate; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; In tetrahydrofuran;

Reference yield:

: 536-74-3
phenylacetylene

: 1374673-07-0
6-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyridazine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium azide; ascorbic acid / copper(l) iodide / water / 6 h / 20 °C / Sonication

2.1: n-butyllithium / hexane; tetrahydrofuran / 0.67 h / -75 °C / Inert atmosphere

2.2: 1 h / -75 - 20 °C

3.1: sodium tetrahydroborate / methanol / 1 h / 20 °C / Inert atmosphere

4.1: sodium hydride / tetrahydrofuran / 16.5 h / 20 °C / Cooling with ice

5.1: sodium carbonate / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / Inert atmosphere

6.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 16 h / 20 °C

With ascorbic acid; sodium tetrahydroborate; n-butyllithium; sodium azide; lithium hydroxide monohydrate; water; sodium hydride; sodium carbonate; 1,1'-bis-(diphenylphosphino)ferrocene; copper(l) iodide; palladium diacetate; In tetrahydrofuran; methanol; hexane; water;