3-chloro-6-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyridazine

Base Information

Chemical Name:3-chloro-6-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyridazine
CAS No.:1374673-05-8
Molecular Formula:C₁₄H₁₁ClFN₅O
Molecular Weight:319.726
Hs Code.:

Synonyms:3-chloro-6-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyridazine

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Chemical Property of 3-chloro-6-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyridazine

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Technology Process of 3-chloro-6-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyridazine

There total 9 articles about 3-chloro-6-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 141-30-0
3,6-dichlorpyridazine

: 1374672-80-6
(3-methyl-5-phenyl-3H-[1,2,3]triazol-4-yl)-methanol

: 1374673-05-8
3-chloro-6-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyridazine

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 20 ℃; for 16.5h; Cooling with ice;

Reference yield: 90.0%

: 141-30-0
3,6-dichlorpyridazine

: 1374645-65-4
[4-(4-fluorophenyl)-1-methyl-1H-1,2,3-triazol-5-yl]methanol

: 1374673-05-8
3-chloro-6-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyridazine

Guidance literature:: [4-(4-fluorophenyl)-1-methyl-1H-1,2,3-triazol-5-yl]methanol; With sodium hydride; In tetrahydrofuran; oil; at 20 ℃; for 0.5h; Cooling with ice;

3,6-dichlorpyridazine; In tetrahydrofuran; oil; at 20 ℃; for 16h; Cooling with ice;

Reference yield:

: 536-74-3
phenylacetylene

: 1374673-05-8
3-chloro-6-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyridazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium azide; ascorbic acid / copper(l) iodide / water / 6 h / 20 °C / Sonication

2.1: n-butyllithium / hexane; tetrahydrofuran / 0.67 h / -75 °C / Inert atmosphere

2.2: 1 h / -75 - 20 °C

3.1: sodium tetrahydroborate / methanol / 1 h / 20 °C / Inert atmosphere

4.1: sodium hydride / tetrahydrofuran / 16.5 h / 20 °C / Cooling with ice

With ascorbic acid; sodium tetrahydroborate; n-butyllithium; sodium azide; sodium hydride; copper(l) iodide; In tetrahydrofuran; methanol; hexane; water;