6-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyridazine-3-carboxylic acid ethyl ester

Base Information

Chemical Name:6-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyridazine-3-carboxylic acid ethyl ester
CAS No.:1374672-35-1
Molecular Formula:C₁₇H₁₆FN₅O₃
Molecular Weight:357.344
Hs Code.:

Synonyms:6-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyridazine-3-carboxylic acid ethyl ester

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Chemical Property of 6-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyridazine-3-carboxylic acid ethyl ester

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Technology Process of 6-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyridazine-3-carboxylic acid ethyl ester

There total 11 articles about 6-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyridazine-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 64-17-5
ethanol

: 201230-82-2
carbon monoxide

: 1374673-05-8
3-chloro-6-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyridazine

: 1374672-35-1
6-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyridazine-3-carboxylic acid ethyl ester

Guidance literature:: With sodium carbonate; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; Inert atmosphere;

Reference yield:

: 536-74-3
phenylacetylene

: 1374672-35-1
6-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyridazine-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium azide; ascorbic acid / copper(l) iodide / water / 6 h / 20 °C / Sonication

2.1: n-butyllithium / hexane; tetrahydrofuran / 0.67 h / -75 °C / Inert atmosphere

2.2: 1 h / -75 - 20 °C

3.1: sodium tetrahydroborate / methanol / 1 h / 20 °C / Inert atmosphere

4.1: sodium hydride / tetrahydrofuran / 16.5 h / 20 °C / Cooling with ice

5.1: sodium carbonate / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / Inert atmosphere

With ascorbic acid; sodium tetrahydroborate; n-butyllithium; sodium azide; sodium hydride; sodium carbonate; 1,1'-bis-(diphenylphosphino)ferrocene; copper(l) iodide; palladium diacetate; In tetrahydrofuran; methanol; hexane; water;

Reference yield:

: 1374672-79-3
3-methyl-5-phenyl-3H-[1,2,3]triazole-4-carbaldehyde

: 1374672-35-1
6-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyridazine-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate / methanol / 1 h / 20 °C / Inert atmosphere

2: sodium hydride / tetrahydrofuran / 16.5 h / 20 °C / Cooling with ice

3: sodium carbonate / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / Inert atmosphere

With sodium tetrahydroborate; sodium hydride; sodium carbonate; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; In tetrahydrofuran; methanol;