(Z)-2-(4'-chloro-[1,1'-biphenyl]-4-yl)-3-(4-(5-((Z)-2-cyano-2-phenylvinyl)-thiophen-3-yl)-phenyl)acrylonitrile

Base Information

Chemical Name:(Z)-2-(4'-chloro-[1,1'-biphenyl]-4-yl)-3-(4-(5-((Z)-2-cyano-2-phenylvinyl)-thiophen-3-yl)-phenyl)acrylonitrile
CAS No.:1401545-58-1
Molecular Formula:C₃₄H₂₁ClN₂S
Molecular Weight:525.073
Hs Code.:

Synonyms:(Z)-2-(4'-chloro-[1,1'-biphenyl]-4-yl)-3-(4-(5-((Z)-2-cyano-2-phenylvinyl)-thiophen-3-yl)-phenyl)acrylonitrile

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Chemical Property of (Z)-2-(4'-chloro-[1,1'-biphenyl]-4-yl)-3-(4-(5-((Z)-2-cyano-2-phenylvinyl)-thiophen-3-yl)-phenyl)acrylonitrile

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Technology Process of (Z)-2-(4'-chloro-[1,1'-biphenyl]-4-yl)-3-(4-(5-((Z)-2-cyano-2-phenylvinyl)-thiophen-3-yl)-phenyl)acrylonitrile

There total 5 articles about (Z)-2-(4'-chloro-[1,1'-biphenyl]-4-yl)-3-(4-(5-((Z)-2-cyano-2-phenylvinyl)-thiophen-3-yl)-phenyl)acrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1401545-49-0
(Z)-2-(4-bromophenyl)-3-(4-(5-((Z)-2-cyano-2-phenylvinyl)thio-phen-3-yl)-phenyl)acrylonitrile

: 1679-18-1
4-Chlorophenylboronic acid

: 1401545-58-1
(Z)-2-(4'-chloro-[1,1'-biphenyl]-4-yl)-3-(4-(5-((Z)-2-cyano-2-phenylvinyl)-thiophen-3-yl)-phenyl)acrylonitrile

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; ethanol; water; at 85 ℃; Inert atmosphere;
DOI:10.1016/j.dyepig.2012.05.019

Reference yield:

: 1353756-31-6
C₁₃H₈BrNS

: 1401545-58-1
(Z)-2-(4'-chloro-[1,1'-biphenyl]-4-yl)-3-(4-(5-((Z)-2-cyano-2-phenylvinyl)-thiophen-3-yl)-phenyl)acrylonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; ethanol; water / 8 h / 85 °C / Inert atmosphere

2: sodium methylate / ethanol / 60 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; ethanol; water / 85 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium methylate; sodium carbonate; In 1,2-dimethoxyethane; ethanol; water; 1: Suzuki coupling / 3: Suzuki coupling;
DOI:10.1016/j.dyepig.2012.05.019

Reference yield:

: 18791-75-8
4-Bromothiophen-2-aldehyde

: 1401545-58-1
(Z)-2-(4'-chloro-[1,1'-biphenyl]-4-yl)-3-(4-(5-((Z)-2-cyano-2-phenylvinyl)-thiophen-3-yl)-phenyl)acrylonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: sodium methylate / ethanol / 4 h / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; ethanol; water / 8 h / 85 °C / Inert atmosphere

3: sodium methylate / ethanol / 60 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; ethanol; water / 85 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium methylate; sodium carbonate; In 1,2-dimethoxyethane; ethanol; water; 2: Suzuki coupling / 4: Suzuki coupling;
DOI:10.1016/j.dyepig.2012.05.019