(1R,2R,3R,5R,6R)-6-((((adamantane-1-carbonyl)oxy)methoxy)carbonyl)-2-amino-3-((3,4-dichlorobenzyl)oxy)-6-fluorobicyclo[3.1.0]hexane-2-carboxylic acid

Base Information

Chemical Name:(1R,2R,3R,5R,6R)-6-((((adamantane-1-carbonyl)oxy)methoxy)carbonyl)-2-amino-3-((3,4-dichlorobenzyl)oxy)-6-fluorobicyclo[3.1.0]hexane-2-carboxylic acid
CAS No.:1431218-25-5
Molecular Formula:C₂₇H₃₀Cl₂FNO₇
Molecular Weight:570.442
Hs Code.:

Synonyms:(1R,2R,3R,5R,6R)-6-((((adamantane-1-carbonyl)oxy)methoxy)carbonyl)-2-amino-3-((3,4-dichlorobenzyl)oxy)-6-fluorobicyclo[3.1.0]hexane-2-carboxylic acid

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Chemical Property of (1R,2R,3R,5R,6R)-6-((((adamantane-1-carbonyl)oxy)methoxy)carbonyl)-2-amino-3-((3,4-dichlorobenzyl)oxy)-6-fluorobicyclo[3.1.0]hexane-2-carboxylic acid

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Technology Process of (1R,2R,3R,5R,6R)-6-((((adamantane-1-carbonyl)oxy)methoxy)carbonyl)-2-amino-3-((3,4-dichlorobenzyl)oxy)-6-fluorobicyclo[3.1.0]hexane-2-carboxylic acid

There total 3 articles about (1R,2R,3R,5R,6R)-6-((((adamantane-1-carbonyl)oxy)methoxy)carbonyl)-2-amino-3-((3,4-dichlorobenzyl)oxy)-6-fluorobicyclo[3.1.0]hexane-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1431218-27-7
C₃₂H₃₄Cl₂FNO₉

: 1431218-25-5
(1R,2R,3R,5R,6R)-6-((((adamantane-1-carbonyl)oxy)methoxy)carbonyl)-2-amino-3-((3,4-dichlorobenzyl)oxy)-6-fluorobicyclo[3.1.0]hexane-2-carboxylic acid

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid; In chloroform; at 20 ℃; for 0.5h; Inert atmosphere;

Reference yield:

: 828-51-3
1-Adamantanecarboxylic acid

: 1431218-25-5
(1R,2R,3R,5R,6R)-6-((((adamantane-1-carbonyl)oxy)methoxy)carbonyl)-2-amino-3-((3,4-dichlorobenzyl)oxy)-6-fluorobicyclo[3.1.0]hexane-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate; tetra(n-butyl)ammonium hydrogensulfate / dichloromethane; water / 4.5 h / 0 - 20 °C / Inert atmosphere

2: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 3 h / 60 °C / Inert atmosphere

3: 1,3-dimethylbarbituric acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / chloroform / 0.5 h / 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid; tetra(n-butyl)ammonium hydrogensulfate; sodium hydrogencarbonate; potassium carbonate; sodium iodide; In dichloromethane; chloroform; water; N,N-dimethyl-formamide;

Reference yield:

: 820244-80-2
(1'R,2'R,3'R,5'R,6'R)-3'-(3,4-dichlorobenzyloxy)-6'-fluoro-3-allyloxycarbonyl-5-oxooxazinone-4-spiro-2'-bicyclo[3.1.0]hexane-6'-carboxylic acid

: 71570-32-6
chloromethyl adamantane-1-carboxylate

: 1431218-25-5
(1R,2R,3R,5R,6R)-6-((((adamantane-1-carbonyl)oxy)methoxy)carbonyl)-2-amino-3-((3,4-dichlorobenzyl)oxy)-6-fluorobicyclo[3.1.0]hexane-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 3 h / 60 °C / Inert atmosphere

2: 1,3-dimethylbarbituric acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / chloroform / 0.5 h / 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid; potassium carbonate; sodium iodide; In chloroform; N,N-dimethyl-formamide;