N-benzyl-5-(4'-methoxyphenyl)-2-phenyl-2,3-dihydropyridin-4(1H)-one

Base Information

• Chemical Name: N-benzyl-5-(4'-methoxyphenyl)-2-phenyl-2,3-dihydropyridin-4(1H)-one
• CAS No.: 1017601-71-6
• Molecular Formula: C₂₅H₂₃NO₂
• Molecular Weight: 369.463
• Mol file: 1017601-71-6.mol

Synonyms:N-benzyl-5-(4'-methoxyphenyl)-2-phenyl-2,3-dihydropyridin-4(1H)-one

Chemical Property of N-benzyl-5-(4'-methoxyphenyl)-2-phenyl-2,3-dihydropyridin-4(1H)-one

Chemical Property:

Purity/Quality:

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Technology Process of N-benzyl-5-(4'-methoxyphenyl)-2-phenyl-2,3-dihydropyridin-4(1H)-one

There total 3 articles about N-benzyl-5-(4'-methoxyphenyl)-2-phenyl-2,3-dihydropyridin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

N-benzyl-2,3-dihydro-2-phenyl-1H-pyridin-4-one (152873-62-6) + potassium 4-(methoxy)phenyltrifluoroborate → N-benzyl-5-(4'-methoxyphenyl)-2-phenyl-2,3-dihydropyridin-4(1H)-one (1017601-71-6)

Guidance literature:

With potassium carbonate; acetic acid; palladium diacetate; copper diacetate; In dimethyl sulfoxide; tert-butyl alcohol; at 60 ℃; for 7h;

DOI:10.1021/ja710221c

Reference yield: 62.0%

1-bromo-4-methoxy-benzene (104-92-7) + C18H16BrNO → N-benzyl-5-(4'-methoxyphenyl)-2-phenyl-2,3-dihydropyridin-4(1H)-one (1017601-71-6)

Guidance literature:

With manganese; triphenylphosphine; cobalt(II) bromide; In acetonitrile; at 23 ℃; for 18h; Inert atmosphere;

DOI:10.1039/c5ob00517e

Reference yield: 50.0%

triethoxy(4-methoxyphenyl)silane (21130-91-6) + N-benzyl-2,3-dihydro-2-phenyl-1H-pyridin-4-one (152873-62-6) → N-benzyl-5-(4'-methoxyphenyl)-2-phenyl-2,3-dihydropyridin-4(1H)-one (1017601-71-6)

Guidance literature:

N-benzyl-2,3-dihydro-2-phenyl-1H-pyridin-4-one; With palladium diacetate; In acetic acid; tert-butyl alcohol; at 65 ℃; for 0.25h;

triethoxy(4-methoxyphenyl)silane; With copper (II)-fluoride; In acetic acid; tert-butyl alcohol; at 20 - 65 ℃; for 3.5h;

DOI:10.1021/ol202202a

upstream raw materials:

N-benzyl-2,3-dihydro-2-phenyl-1H-pyridin-4-one

triethoxy(4-methoxyphenyl)silane

1-bromo-4-methoxy-benzene