1,5-anhydro-2,3,4,6-tetra-O-benzyl-1,2-C-(dichloromethylene)-α-D-glycero-L-altro-hexitol

Base Information

• Chemical Name: 1,5-anhydro-2,3,4,6-tetra-O-benzyl-1,2-C-(dichloromethylene)-α-D-glycero-L-altro-hexitol
• CAS No.: 946416-39-3
• Molecular Formula: C₃₅H₃₄Cl₂O₅
• Molecular Weight: 605.558
• Mol file: 946416-39-3.mol

Synonyms:1,5-anhydro-2,3,4,6-tetra-O-benzyl-1,2-C-(dichloromethylene)-α-D-glycero-L-altro-hexitol

Chemical Property of 1,5-anhydro-2,3,4,6-tetra-O-benzyl-1,2-C-(dichloromethylene)-α-D-glycero-L-altro-hexitol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,5-anhydro-2,3,4,6-tetra-O-benzyl-1,2-C-(dichloromethylene)-α-D-glycero-L-altro-hexitol

There total 1 articles about 1,5-anhydro-2,3,4,6-tetra-O-benzyl-1,2-C-(dichloromethylene)-α-D-glycero-L-altro-hexitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

chloroform (67-66-3,8013-54-5) + 1,5-anhydro-2,3,4,6-tetra-O-benzyl-D-lyxo-hex-1-enitol (138511-92-9) → 1,5-anhydro-2,3,4,6-tetra-O-benzyl-1,2-C-(dichloromethylene)-α-D-glycero-L-altro-hexitol (946416-39-3)

Guidance literature:

With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; at 40 ℃; for 2h;

DOI:10.1021/jo070444e

Reference yield: 95.0%

1,5-anhydro-2,3,4,6-tetra-O-benzyl-1,2-C-(dichloromethylene)-α-D-glycero-L-altro-hexitol (946416-39-3) + sodium methylate (124-41-4) → methyl 2-chloro-2-deoxy-3,4,5,7-tetra-O-benzyl-α-D-lyxo-hept-2-enoseptanoside (946416-40-6)

Guidance literature:

In 1,4-dioxane; methanol; for 48h; Heating;

DOI:10.1021/jo070444e

Reference yield:

1,5-anhydro-2,3,4,6-tetra-O-benzyl-1,2-C-(dichloromethylene)-α-D-glycero-L-altro-hexitol (946416-39-3) → methyl 4,5,7-tri-O-benzyl-α-D-lyxo-sept-2,3-diuloside (946416-41-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / methanol; dioxane / 48 h / Heating

2: 75 percent / RuCl₃; NaIO₄ / acetonitrile; CCl₄; H₂O / 8 h / 20 °C

With ruthenium trichloride; sodium periodate; In 1,4-dioxane; methanol; tetrachloromethane; water; acetonitrile;

DOI:10.1021/jo070444e

upstream raw materials:

chloroform

1,5-anhydro-2,3,4,6-tetra-O-benzyl-D-lyxo-hex-1-enitol

Downstream raw materials:

methyl 2-chloro-2-deoxy-3,4,5,7-tetra-O-benzyl-α-D-lyxo-hept-2-enoseptanoside

methyl 4,5,7-tri-O-benzyl-α-D-lyxo-sept-2,3-diuloside

methyl 4,5,7-tri-O-benzyl-α-D-glycero-L-altro-septanoside