tert-butyl ((3S)-1-(3-((2-(2,6-difluorophenyl)-imidazo[1,5-b]pyridazin-7-yl)amino)-4-pyridinyl)-3-piperidinyl)carbamate

Base Information

Chemical Name:tert-butyl ((3S)-1-(3-((2-(2,6-difluorophenyl)-imidazo[1,5-b]pyridazin-7-yl)amino)-4-pyridinyl)-3-piperidinyl)carbamate
CAS No.:1405128-81-5
Molecular Formula:C₂₇H₂₉F₂N₇O₂
Molecular Weight:521.57
Hs Code.:

Synonyms:tert-butyl ((3S)-1-(3-((2-(2,6-difluorophenyl)-imidazo[1,5-b]pyridazin-7-yl)amino)-4-pyridinyl)-3-piperidinyl)carbamate

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Chemical Property of tert-butyl ((3S)-1-(3-((2-(2,6-difluorophenyl)-imidazo[1,5-b]pyridazin-7-yl)amino)-4-pyridinyl)-3-piperidinyl)carbamate

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Technology Process of tert-butyl ((3S)-1-(3-((2-(2,6-difluorophenyl)-imidazo[1,5-b]pyridazin-7-yl)amino)-4-pyridinyl)-3-piperidinyl)carbamate

There total 9 articles about tert-butyl ((3S)-1-(3-((2-(2,6-difluorophenyl)-imidazo[1,5-b]pyridazin-7-yl)amino)-4-pyridinyl)-3-piperidinyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1405127-64-1
3-(azidomethyl)-6-(2,6-difluorophenyl)pyridazine

: 1405127-81-2
tert-butyl ((3S)-1-(3-isothiocyanato-4-pyridinyl)-3-piperidinyl)carbamate

: 1405128-81-5
tert-butyl ((3S)-1-(3-((2-(2,6-difluorophenyl)-imidazo[1,5-b]pyridazin-7-yl)amino)-4-pyridinyl)-3-piperidinyl)carbamate

Guidance literature:: With trimethylphosphane; In tetrahydrofuran; at 0 - 20 ℃; for 3h;
DOI:10.1016/j.bmcl.2016.09.067

Reference yield:

: 1618-47-9
3-iodo-6-methylpyridazine

: 1405128-81-5
tert-butyl ((3S)-1-(3-((2-(2,6-difluorophenyl)-imidazo[1,5-b]pyridazin-7-yl)amino)-4-pyridinyl)-3-piperidinyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: bis[di-tert-butyl-(4-dimethylaminophenyl)phosphine]palladium (II) dichloride / tetrahydrofuran / 1 h / 60 °C / Inert atmosphere; Sealed tube

2: trichloroisocyanuric acid / 1,2-dichloro-ethane / 90 °C

3: sodium azide / N,N-dimethyl-formamide / 3 h / 20 °C

4: trimethylphosphane / tetrahydrofuran / 0.5 h / Inert atmosphere; Cooling with ice

With sodium azide; trichloroisocyanuric acid; trimethylphosphane; bis[di-tert-butyl-(4-dimethylaminophenyl)phosphine]palladium (II) dichloride; In tetrahydrofuran; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 1121-79-5
3-chloro-6-methylpyridazine

: 1405128-81-5
tert-butyl ((3S)-1-(3-((2-(2,6-difluorophenyl)-imidazo[1,5-b]pyridazin-7-yl)amino)-4-pyridinyl)-3-piperidinyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen iodide / water / 2 h / 100 °C

2: bis[di-tert-butyl-(4-dimethylaminophenyl)phosphine]palladium (II) dichloride / tetrahydrofuran / 1 h / 60 °C / Inert atmosphere; Sealed tube

3: trichloroisocyanuric acid / 1,2-dichloro-ethane / 90 °C

4: sodium azide / N,N-dimethyl-formamide / 3 h / 20 °C

5: trimethylphosphane / tetrahydrofuran / 0.5 h / Inert atmosphere; Cooling with ice

With sodium azide; trichloroisocyanuric acid; hydrogen iodide; trimethylphosphane; bis[di-tert-butyl-(4-dimethylaminophenyl)phosphine]palladium (II) dichloride; In tetrahydrofuran; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;