1-(4-Nitrophenyl)-4-piperidinol

Base Information

• Chemical Name: 1-(4-Nitrophenyl)-4-piperidinol
• CAS No.: 79421-45-7
• Molecular Formula: C11H14 N2 O3
• Molecular Weight: 222.244
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID30346645
• Nikkaji Number: J1.399.394G
• Wikidata: Q82119796
• Mol file: 79421-45-7.mol

Synonyms:1-(4-nitrophenyl)piperidin-4-ol;79421-45-7;1-(4-Nitrophenyl)-4-piperidinol;4-Hydroxy-1-(4-nitrophenyl)piperidine;4-Piperidinol, 1-(4-nitrophenyl)-;1-(4-nitrophenyl)-4-hydroxypiperidine;1-(4-Nitro-phenyl)-piperidin-4-ol;Oprea1_748408;SCHEMBL27789;DTXSID30346645;1-(4-nitrophenyl)piperi dine-4-ol;CL8008;MFCD00215518;1-(4-Nitrophenyl)-4-piperidinol #;AKOS000600310;4-hydroxy-N-(4-nitrophenyl)piperidine;MB00937;CS-0146876;FT-0680441;5F-952;A864864;J-503371

Chemical Property of 1-(4-Nitrophenyl)-4-piperidinol

Chemical Property:

• Vapor Pressure: 7.42E-08mmHg at 25°C
• Melting Point: 114-116 °C(Solv: isopropanol (67-63-0))
• Refractive Index: 1.611
• Boiling Point: 421.5°C at 760 mmHg
• PKA: 14.69±0.20(Predicted)
• Flash Point: 208.7°C
• PSA: 69.29000
• Density: 1.303g/cm³
• LogP: 2.14410
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 222.10044231
• Heavy Atom Count: 16
• Complexity: 238

Purity/Quality:

98%min ^*data from raw suppliers

1-(4-Nitrophenyl)-4-piperidinol ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCC1O)C2=CC=C(C=C2)[N+](=O)[O-]

Technology Process of 1-(4-Nitrophenyl)-4-piperidinol

There total 5 articles about 1-(4-Nitrophenyl)-4-piperidinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-HYDROXYPIPERIDINE (5382-16-1) + 4-chlorobenzonitrile (100-00-5) → 4-(4-hydroxypiperidinyl)nitrobenzene (79421-45-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl acetamide; at 130 ℃; for 3h;

Reference yield: 93.0%

4-HYDROXYPIPERIDINE (5382-16-1) + 4-Fluoronitrobenzene (350-46-9,178603-76-4) → 4-(4-hydroxypiperidinyl)nitrobenzene (79421-45-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 85 ℃; for 1h;

Reference yield: 42.0%

1-(4-nitrophenyl)piperidine (6574-15-8) → 4-(4-hydroxypiperidinyl)nitrobenzene (79421-45-7)

Guidance literature:

In ethanol; water; Beauveria sulfurescens ATCC 7159;

upstream raw materials:

4-HYDROXYPIPERIDINE

4-Fluoronitrobenzene

1-(4-nitrophenyl)piperidine

4-chlorobenzonitrile

Downstream raw materials:

4-(4-hydroxypiperidin-1-yl)aniline

N-(4-(4-hydroxypiperidin-1-yl)-phenyl)-4-((1-methylpyrrol-2-yl)-carbonyl)-1-piperazinecarboxamide

[1-(4-Amino-phenyl)-piperidin-4-yl]-dimethyl-amine

N,N-dimethyl-1-(4-nitrophenyl)piperidin-4-amine

Refernces

• 1、 -. "Indazole formamide compound as well as preparation method and application thereof". Paragraph 0084-0087. . Retrieved 2021/02/16.
• 2、 -. "HETEROCYCLIC COMPOUNDS AND USES THEREOF". Paragraph 0513-0515. . Retrieved 2019/04/25.