5-(2-ethoxyphenyl)-3-phenyl-1-(pyridin-3-yl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one

Base Information

Chemical Name:5-(2-ethoxyphenyl)-3-phenyl-1-(pyridin-3-yl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one
CAS No.:1370409-64-5
Molecular Formula:C₂₄H₁₉N₅O₂
Molecular Weight:409.447
Hs Code.:

Synonyms:5-(2-ethoxyphenyl)-3-phenyl-1-(pyridin-3-yl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one

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Chemical Property of 5-(2-ethoxyphenyl)-3-phenyl-1-(pyridin-3-yl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one

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Technology Process of 5-(2-ethoxyphenyl)-3-phenyl-1-(pyridin-3-yl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one

There total 5 articles about 5-(2-ethoxyphenyl)-3-phenyl-1-(pyridin-3-yl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1120-90-7
3-iodopyridine

: 1370409-60-1
5-(2-ethoxyphenyl)-3-phenyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one

: 1370409-64-5
5-(2-ethoxyphenyl)-3-phenyl-1-(pyridin-3-yl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one

Guidance literature:: With copper(l) iodide; caesium carbonate; trans-1,2-cyclohexanediamine; In N,N-dimethyl-formamide; at 110 ℃; Inert atmosphere;
DOI:10.1016/j.bmcl.2012.01.119

Reference yield:

: ethyl 4-(2-ethoxybenzamido)-3-phenyl-1H-pyrazole-5-carboxylate

: 1370409-64-5
5-(2-ethoxyphenyl)-3-phenyl-1-(pyridin-3-yl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: ammonia / 1,4-dioxane; water / 72 h / 20 °C

2: sodium ethanolate / ethanol / 0.17 h / 120 °C / Microwave irradiation

3: copper(l) iodide; caesium carbonate; trans-1,2-cyclohexanediamine / N,N-dimethyl-formamide / 110 °C / Inert atmosphere

With copper(l) iodide; ammonia; sodium ethanolate; caesium carbonate; trans-1,2-cyclohexanediamine; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.01.119

Reference yield:

: 134-11-2
2-ethoxybenzoic acid

: 1370409-64-5
5-(2-ethoxyphenyl)-3-phenyl-1-(pyridin-3-yl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / 1,2-dichloro-ethane / 0.33 h / 120 °C / Microwave irradiation

2: ammonia / 1,4-dioxane; water / 72 h / 20 °C

3: sodium ethanolate / ethanol / 0.17 h / 120 °C / Microwave irradiation

4: copper(l) iodide; caesium carbonate; trans-1,2-cyclohexanediamine / N,N-dimethyl-formamide / 110 °C / Inert atmosphere

With copper(l) iodide; ammonia; sodium ethanolate; caesium carbonate; triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; trans-1,2-cyclohexanediamine; In 1,4-dioxane; ethanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.01.119