Ethyl_5-[4-(methylsulfonyl)phenoxy]-7-(tetrahydro-2H-pyran-4-yloxy)-1H-indole-2-carboxylate

Base Information

Chemical Name:Ethyl_5-[4-(methylsulfonyl)phenoxy]-7-(tetrahydro-2H-pyran-4-yloxy)-1H-indole-2-carboxylate
CAS No.:1233540-67-4
Molecular Formula:C₂₃H₂₅NO₇S
Molecular Weight:459.52
Hs Code.:

Synonyms:Ethyl_5-[4-(methylsulfonyl)phenoxy]-7-(tetrahydro-2H-pyran-4-yloxy)-1H-indole-2-carboxylate

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Chemical Property of Ethyl_5-[4-(methylsulfonyl)phenoxy]-7-(tetrahydro-2H-pyran-4-yloxy)-1H-indole-2-carboxylate

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Technology Process of Ethyl_5-[4-(methylsulfonyl)phenoxy]-7-(tetrahydro-2H-pyran-4-yloxy)-1H-indole-2-carboxylate

There total 8 articles about Ethyl_5-[4-(methylsulfonyl)phenoxy]-7-(tetrahydro-2H-pyran-4-yloxy)-1H-indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2081-44-9
Tetrahydro-pyran-4-ol

: 1191102-65-4
ethyl 7-hydroxy-5-[4-(methylsulfonyl)phenoxy]-1H-indole-2-carboxylate

: 1233540-67-4
Ethyl_5-[4-(methylsulfonyl)phenoxy]-7-(tetrahydro-2H-pyran-4-yloxy)-1H-indole-2-carboxylate

Guidance literature:: With tributylphosphine; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; at 70 ℃; for 20h;

Reference yield:

: 1191102-62-1
ethyl 7-(benzyloxy)-5-[4-(methylsulfonyl)phenoxy]-1H-indole-2-carboxylate

: 1233540-67-4
Ethyl_5-[4-(methylsulfonyl)phenoxy]-7-(tetrahydro-2H-pyran-4-yloxy)-1H-indole-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / ethanol; water; tetrahydrofuran / 4 h / 10 - 35 °C

2: 1,1'-azodicarbonyl-dipiperidine; tributylphosphine / tetrahydrofuran / 20 h / 70 °C

With tributylphosphine; hydrogen; 1,1'-azodicarbonyl-dipiperidine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; water;

Reference yield:

: 129464-01-3
2-(benzyloxy)-4-fluoro-1-nitrobenzene

: 1233540-67-4
Ethyl_5-[4-(methylsulfonyl)phenoxy]-7-(tetrahydro-2H-pyran-4-yloxy)-1H-indole-2-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

2.1: Oxone / water; tetrahydrofuran; methanol / 4 h / 10 - 35 °C

3.1: water; calcium chloride; iron / ethanol / 2 h / 80 °C

4.1: hydrogenchloride; sodium nitrite / acetonitrile; ethanol; water / -5 - 10 °C

4.2: 2.67 h / -13 - -11 °C

5.1: toluene-4-sulfonic acid / toluene / 0.17 h / 80 °C

6.1: hydrogen / palladium 10% on activated carbon / ethanol; water; tetrahydrofuran / 4 h / 10 - 35 °C

7.1: 1,1'-azodicarbonyl-dipiperidine; tributylphosphine / tetrahydrofuran / 20 h / 70 °C

With hydrogenchloride; Oxone; tributylphosphine; water; hydrogen; iron; potassium carbonate; toluene-4-sulfonic acid; calcium chloride; 1,1'-azodicarbonyl-dipiperidine; sodium nitrite; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; toluene; acetonitrile;