1-{2-O-[(2-(2,2,2-trifluoroacetamido)ethoxy)methyl]-5-O-(4-methoxytrityl)-β-D-ribofuranosyl}uracil

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Chemical Name:1-{2-O-[(2-(2,2,2-trifluoroacetamido)ethoxy)methyl]-5-O-(4-methoxytrityl)-β-D-ribofuranosyl}uracil
CAS No.:1042665-10-0
Molecular Formula:C₃₄H₃₄F₃N₃O₉
Molecular Weight:685.654
Hs Code.:

Synonyms:1-{2-O-[(2-(2,2,2-trifluoroacetamido)ethoxy)methyl]-5-O-(4-methoxytrityl)-β-D-ribofuranosyl}uracil

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Chemical Property of 1-{2-O-[(2-(2,2,2-trifluoroacetamido)ethoxy)methyl]-5-O-(4-methoxytrityl)-β-D-ribofuranosyl}uracil

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Technology Process of 1-{2-O-[(2-(2,2,2-trifluoroacetamido)ethoxy)methyl]-5-O-(4-methoxytrityl)-β-D-ribofuranosyl}uracil

There total 4 articles about 1-{2-O-[(2-(2,2,2-trifluoroacetamido)ethoxy)methyl]-5-O-(4-methoxytrityl)-β-D-ribofuranosyl}uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 14470-28-1
mono-4-methoxytrityl chloride

: 1042665-03-1
1-{2-O-[(2-(2,2,2-trifluoroacetamido)ethoxy)methyl]-β-D-ribofuranosyl}uracil

: 1042665-10-0
1-{2-O-[(2-(2,2,2-trifluoroacetamido)ethoxy)methyl]-5-O-(4-methoxytrityl)-β-D-ribofuranosyl}uracil

Guidance literature:: With pyridine; at 20 ℃; for 16h;
DOI:10.1016/j.tet.2008.04.110

Reference yield:

: 174497-93-9
2'-O-methylthiomethyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

: 1042665-10-0
1-{2-O-[(2-(2,2,2-trifluoroacetamido)ethoxy)methyl]-5-O-(4-methoxytrityl)-β-D-ribofuranosyl}uracil

Guidance literature:: Multi-step reaction with 3 steps

1: N-iodosuccinimide; triflic acid / tetrahydrofuran; 1,2-dichloro-ethane

2: tetra-n-butylammonium fluoride / tetrahydrofuran

3: pyridine

With pyridine; N-iodo-succinimide; trifluorormethanesulfonic acid; tetrabutyl ammonium fluoride; In tetrahydrofuran; 1,2-dichloro-ethane;
DOI:10.1081/NCN-100002561

Reference yield:

: 69304-38-7
3',5'-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

: 1042665-10-0
1-{2-O-[(2-(2,2,2-trifluoroacetamido)ethoxy)methyl]-5-O-(4-methoxytrityl)-β-D-ribofuranosyl}uracil

Guidance literature:: Multi-step reaction with 4 steps

1: acetic anhydride; acetic acid

2: N-iodosuccinimide; triflic acid / tetrahydrofuran; 1,2-dichloro-ethane

3: tetra-n-butylammonium fluoride / tetrahydrofuran

4: pyridine

With pyridine; N-iodo-succinimide; trifluorormethanesulfonic acid; tetrabutyl ammonium fluoride; acetic anhydride; acetic acid; In tetrahydrofuran; 1,2-dichloro-ethane;
DOI:10.1081/NCN-100002561