(1R,2R,3R)-3-Benzyloxymethyl-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-1-methyl-4-methylene-cyclohexanecarbaldehyde

Base Information

Chemical Name:(1R,2R,3R)-3-Benzyloxymethyl-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-1-methyl-4-methylene-cyclohexanecarbaldehyde
CAS No.:192633-01-5
Molecular Formula:C₂₂H₃₀O₄
Molecular Weight:358.478
Hs Code.:

Synonyms:(1R,2R,3R)-3-Benzyloxymethyl-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-1-methyl-4-methylene-cyclohexanecarbaldehyde

Suppliers and Price of (1R,2R,3R)-3-Benzyloxymethyl-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-1-methyl-4-methylene-cyclohexanecarbaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R,2R,3R)-3-Benzyloxymethyl-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-1-methyl-4-methylene-cyclohexanecarbaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R,2R,3R)-3-Benzyloxymethyl-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-1-methyl-4-methylene-cyclohexanecarbaldehyde

There total 8 articles about (1R,2R,3R)-3-Benzyloxymethyl-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-1-methyl-4-methylene-cyclohexanecarbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 192633-00-4
Methanesulfonic acid (1S,2S,3R,4R)-2-benzyloxymethyl-3-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-5-hydroxy-4-methyl-bicyclo[2.2.2]oct-1-yl ester

: 192633-01-5
(1R,2R,3R)-3-Benzyloxymethyl-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-1-methyl-4-methylene-cyclohexanecarbaldehyde

Guidance literature:: With potassium tert-butylate; In tert-butyl alcohol; at 25 ℃; for 1h;
DOI:10.1016/S0040-4039(97)01069-1

Reference yield:

: 100-39-0
benzyl bromide

: 192633-01-5
(1R,2R,3R)-3-Benzyloxymethyl-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-1-methyl-4-methylene-cyclohexanecarbaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1: NaH / tetrahydrofuran; dimethylformamide / 0 °C

2: PCC / Ambient temperature

3: TsOH / acetone; H₂O

4: pyridine / Ambient temperature

5: 96 percent / NaBH₄ / methanol / 0 °C

6: 81 percent / t-BuOK, / 2-methyl-propan-2-ol / 1 h / 25 °C

With pyridine; sodium tetrahydroborate; potassium tert-butylate; sodium hydride; toluene-4-sulfonic acid; pyridinium chlorochromate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;
DOI:10.1016/S0040-4039(97)01069-1

Reference yield:

: 147728-68-5
methyl (1S, 2R, 3R, 4R, 4'S)-1-methoxymethyloxy-4-methyl-3-(2',2'-dimethyl-1',3'-dioxolan-4'-yl)-5-oxobicyclo[2.2.2]octane-2-carboxylate

: 192633-01-5
(1R,2R,3R)-3-Benzyloxymethyl-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-1-methyl-4-methylene-cyclohexanecarbaldehyde

Guidance literature:: Multi-step reaction with 7 steps

1: LiAlH / tetrahydrofuran / Ambient temperature

2: NaH / tetrahydrofuran; dimethylformamide / 0 °C

3: PCC / Ambient temperature

4: TsOH / acetone; H₂O

5: pyridine / Ambient temperature

6: 96 percent / NaBH₄ / methanol / 0 °C

7: 81 percent / t-BuOK, / 2-methyl-propan-2-ol / 1 h / 25 °C

With pyridine; sodium tetrahydroborate; potassium tert-butylate; sodium hydride; toluene-4-sulfonic acid; pyridinium chlorochromate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;
DOI:10.1016/S0040-4039(97)01069-1