Technology Process of 6-(S)-methoxy-6-phenylcarbamoyl-hexanoic acid methyl ester
There total 6 articles about 6-(S)-methoxy-6-phenylcarbamoyl-hexanoic acid methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 0 - 20 ℃;
for 24h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: hydrogen / palladium 10% on activated carbon / methanol / 4 - 24 h
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 - 20 °C
3: trichloroisocyanuric acid; sodium hydrogencarbonate; sodium bromide / 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / water; acetone / 3.5 h / 0 - 20 °C
4: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine / dichloromethane / 24 h / 0 - 20 °C
With
trichloroisocyanuric acid; tetrabutyl ammonium fluoride; hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; sodium bromide;
2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; dichloromethane; water; acetone;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: potassium hexamethylsilazane / toluene / 1.5 h / -78 - 20 °C
2: dichloro(tricyclohexylphosphino)(benzylidene)(1,3-dimesityl-4,5-dihydroimidazol-2-ylidene)ruthenium(III) / dichloromethane / 20 °C
3: hydrogen / palladium 10% on activated carbon / methanol / 4 - 24 h
4: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 - 20 °C
5: trichloroisocyanuric acid; sodium hydrogencarbonate; sodium bromide / 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / water; acetone / 3.5 h / 0 - 20 °C
6: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine / dichloromethane / 24 h / 0 - 20 °C
With
trichloroisocyanuric acid; tetrabutyl ammonium fluoride; hydrogen; potassium hexamethylsilazane; sodium hydrogencarbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; sodium bromide;
dichloro(tricyclohexylphosphino)(benzylidene)(1,3-dimesityl-4,5-dihydroimidazol-2-ylidene)ruthenium(III); 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; dichloromethane; water; acetone; toluene;
