2,2,2-trifluoro-N-(2-{(4-methoxy-phenyl)-[2-(2,2,2-trifluoro-acetylamino)-ethoxy]-methoxy}-ethyl)-acetamide

Base Information

• Chemical Name: 2,2,2-trifluoro-N-(2-{(4-methoxy-phenyl)-[2-(2,2,2-trifluoro-acetylamino)-ethoxy]-methoxy}-ethyl)-acetamide
• CAS No.: 605674-81-5
• Molecular Formula: C₁₆H₁₈F₆N₂O₅
• Molecular Weight: 432.32
• Mol file: 605674-81-5.mol

Synonyms:2,2,2-trifluoro-N-(2-{(4-methoxy-phenyl)-[2-(2,2,2-trifluoro-acetylamino)-ethoxy]-methoxy}-ethyl)-acetamide

Chemical Property of 2,2,2-trifluoro-N-(2-{(4-methoxy-phenyl)-[2-(2,2,2-trifluoro-acetylamino)-ethoxy]-methoxy}-ethyl)-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2,2-trifluoro-N-(2-{(4-methoxy-phenyl)-[2-(2,2,2-trifluoro-acetylamino)-ethoxy]-methoxy}-ethyl)-acetamide

There total 1 articles about 2,2,2-trifluoro-N-(2-{(4-methoxy-phenyl)-[2-(2,2,2-trifluoro-acetylamino)-ethoxy]-methoxy}-ethyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

N-(2-hydroxyethyl)-2,2,2-trifluoroacetamide (6974-29-4) + 4-methoxy-benzaldehyde (123-11-5) → 2,2,2-trifluoro-N-(2-{(4-methoxy-phenyl)-[2-(2,2,2-trifluoro-acetylamino)-ethoxy]-methoxy}-ethyl)-acetamide (605674-81-5)

Guidance literature:

With sulfuric acid; In tetrahydrofuran; at 45 ℃; for 24h; Molecular sieve; Inert atmosphere;

DOI:10.1021/ja404491r

Reference yield: 84.0%

2,2,2-trifluoro-N-(2-{(4-methoxy-phenyl)-[2-(2,2,2-trifluoro-acetylamino)-ethoxy]-methoxy}-ethyl)-acetamide (605674-81-5) → 2-[(2-amino-ethoxy)-(4-methoxy-phenyl)-methoxy]-ethylamine

Guidance literature:

With water; sodium hydroxide; at 20 ℃; for 4h;

DOI:10.1021/jacs.6b11181

Reference yield:

2,2,2-trifluoro-N-(2-{(4-methoxy-phenyl)-[2-(2,2,2-trifluoro-acetylamino)-ethoxy]-methoxy}-ethyl)-acetamide (605674-81-5) → N-(2-hydroxyethyl)-2,2,2-trifluoroacetamide (6974-29-4) + 4-methoxy-benzaldehyde (123-11-5)

Guidance literature:

In aq. phosphate buffer; [D₃]acetonitrile; water-d2; at 20 ℃; pH=5; Kinetics;

DOI:10.1021/jacs.6b11181

upstream raw materials:

N-(2-hydroxyethyl)-2,2,2-trifluoroacetamide

4-methoxy-benzaldehyde

Downstream raw materials:

N-{2-[(2-acryloylamino-ethoxy)-(4-methoxy-phenyl)-methoxy]-ethyl}-acrylamide

N-(2-hydroxyethyl)-2,2,2-trifluoroacetamide

4-methoxy-benzaldehyde