Technology Process of benzyl (2-{6,6-dimethyl-1-[2-(trimethylsilyl)ethoxymethyl]-4,5,6,7-tetrahydro-1H-indazol-3-yl}-1-[2-(trimethylsilyl)ethoxymethyl]-1H-indol-6-yl)carbamate
There total 14 articles about benzyl (2-{6,6-dimethyl-1-[2-(trimethylsilyl)ethoxymethyl]-4,5,6,7-tetrahydro-1H-indazol-3-yl}-1-[2-(trimethylsilyl)ethoxymethyl]-1H-indol-6-yl)carbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
diphenyl phosphoryl azide; triethylamine;
In
toluene;
at 115 ℃;
for 2h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C
1.2: 2 h / 20 °C
2.1: dmap / tetrahydrofuran / 2 h / 20 °C
3.1: lithium diisopropyl amide; Triisopropyl borate / hexane; tetrahydrofuran / 2.5 h / -5 °C
3.2: Cooling with ice
4.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane; water / 0.25 h / 110 °C / Inert atmosphere
5.1: sodium hydroxide; water / tetrahydrofuran; methanol / 0.5 h / Cooling with ice
5.2: pH 5
6.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / -10 °C / Inert atmosphere
6.2: 2 h
7.1: sodium hydroxide; water / tetrahydrofuran; methanol / 2 h / 60 °C
7.2: pH 5
8.1: triethylamine; diphenyl phosphoryl azide / toluene / 2 h / 115 °C / Inert atmosphere
With
potassium phosphate; Triisopropyl borate; diphenyl phosphoryl azide; water; sodium hydride; potassium carbonate; triethylamine; sodium hydroxide; lithium diisopropyl amide;
dmap; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
tetrahydrofuran; 1,4-dioxane; methanol; hexane; water; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: lithium diisopropyl amide; Triisopropyl borate / hexane; tetrahydrofuran / 2.5 h / -5 °C
1.2: Cooling with ice
2.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane; water / 0.25 h / 110 °C / Inert atmosphere
3.1: sodium hydroxide; water / tetrahydrofuran; methanol / 0.5 h / Cooling with ice
3.2: pH 5
4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / -10 °C / Inert atmosphere
4.2: 2 h
5.1: sodium hydroxide; water / tetrahydrofuran; methanol / 2 h / 60 °C
5.2: pH 5
6.1: triethylamine; diphenyl phosphoryl azide / toluene / 2 h / 115 °C / Inert atmosphere
With
potassium phosphate; Triisopropyl borate; diphenyl phosphoryl azide; water; sodium hydride; triethylamine; sodium hydroxide; lithium diisopropyl amide;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
In
tetrahydrofuran; 1,4-dioxane; methanol; hexane; water; N,N-dimethyl-formamide; toluene;
![2-{6,6-dimethyl-1-[2-(trimethylsilyl)ethoxymethyl]-4,5,6,7-tetrahydro-1H-indazol-3-yl}-1-[2-(trimethylsilyl)ethoxymethyl]-1H-indole-6-carboxylic acid](/Databaselist/images/loading.webp)
