(1R-(1α,2β,4α))-2-<<(1,1,dimethylethyl)dimethylsilyl>oxy>-4-methylcyclohexanemethanol

Base Information

Chemical Name:(1R-(1α,2β,4α))-2-<<(1,1,dimethylethyl)dimethylsilyl>oxy>-4-methylcyclohexanemethanol
CAS No.:145668-38-8
Molecular Formula:C₁₄H₃₀O₂Si
Molecular Weight:258.476
Hs Code.:

Synonyms:(1R-(1α,2β,4α))-2-<<(1,1,dimethylethyl)dimethylsilyl>oxy>-4-methylcyclohexanemethanol

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Chemical Property of (1R-(1α,2β,4α))-2-<<(1,1,dimethylethyl)dimethylsilyl>oxy>-4-methylcyclohexanemethanol

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Technology Process of (1R-(1α,2β,4α))-2-<<(1,1,dimethylethyl)dimethylsilyl>oxy>-4-methylcyclohexanemethanol

There total 4 articles about (1R-(1α,2β,4α))-2-<<(1,1,dimethylethyl)dimethylsilyl>oxy>-4-methylcyclohexanemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 145668-37-7
trans-(1R)-2-<<(1,1,-dimethylethyl)dimethylsilyl>oxy>-4-methylenecyclohexanemethanol

: 145668-38-8
(1R-(1α,2β,4α))-2-<<(1,1,dimethylethyl)dimethylsilyl>oxy>-4-methylcyclohexanemethanol

: (1R-(1α,2β,4β))-2-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-4-methylcyclohexanemethanol

Guidance literature:: With hydrogen; Wilkinson's catalyst; In dichloromethane; for 16h; under 3620.04 Torr; Ambient temperature;
DOI:10.1021/jo00056a013

Reference yield:

: 1779-49-3
Methyltriphenylphosphonium bromide

: 145668-38-8
(1R-(1α,2β,4α))-2-<<(1,1,dimethylethyl)dimethylsilyl>oxy>-4-methylcyclohexanemethanol

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) potassium tert-butoxide / 1.) THF, 2.) THF, r.t., 20 min

2: 86 percent / DIBAL-H / CH₂Cl₂ / 0.25 h / -50 deg C to 0 deg C

3: 78 percent / H₂ / Rh(Ph₃P)3Cl / CH₂Cl₂ / 16 h / 3620.04 Torr / Ambient temperature

With potassium tert-butylate; hydrogen; diisobutylaluminium hydride; Wilkinson's catalyst; In dichloromethane;
DOI:10.1021/jo00056a013

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 145668-38-8
(1R-(1α,2β,4α))-2-<<(1,1,dimethylethyl)dimethylsilyl>oxy>-4-methylcyclohexanemethanol

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) potassium tert-butoxide / 1.) THF, 2.) THF, r.t., 20 min

2: 86 percent / DIBAL-H / CH₂Cl₂ / 0.25 h / -50 deg C to 0 deg C

3: 78 percent / H₂ / Rh(Ph₃P)3Cl / CH₂Cl₂ / 16 h / 3620.04 Torr / Ambient temperature

With potassium tert-butylate; hydrogen; diisobutylaluminium hydride; Wilkinson's catalyst; In dichloromethane;
DOI:10.1021/jo00056a013