-(R)-alanyl>-(S)-pyroglutamic acid tert-butyl ester

Base Information

Chemical Name:-(R)-alanyl>-(S)-pyroglutamic acid tert-butyl ester
CAS No.:98049-20-8
Molecular Formula:C₂₄H₃₄N₂O₆
Molecular Weight:446.544
Hs Code.:

<N-<1(S)-(ethoxycarbonyl)-3-phenylpropyl>-(R)-alanyl>-(S)-pyroglutamic acid tert-butyl ester

Synonyms:-(R)-alanyl>-(S)-pyroglutamic acid tert-butyl ester

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Chemical Property of -(R)-alanyl>-(S)-pyroglutamic acid tert-butyl ester

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Technology Process of -(R)-alanyl>-(S)-pyroglutamic acid tert-butyl ester

There total 5 articles about -(R)-alanyl>-(S)-pyroglutamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 943-73-7
D-homophenylalanine

: 98049-20-8
-(R)-alanyl>-(S)-pyroglutamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / HCl / 2 h / Heating

2: NaOH, H₂ / 5percent Pd/C / ethanol / 25 °C / 2172.02 - 4654.3 Torr

3: DCC / 1,2-dimethoxy-ethane; CHCl₃ / 25 °C

4: 1.) NaH / 1.) toluene, 25 deg C, 30 min, 2.) toluene, overnight

With hydrogenchloride; sodium hydroxide; hydrogen; sodium hydride; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1,2-dimethoxyethane; ethanol; chloroform;
DOI:10.1021/jm00149a009

Reference yield:

: 90891-21-7
L-(+)-α-amino-4-phenylbutyric acid ethyl ester hydrochloride

: 98049-20-8
-(R)-alanyl>-(S)-pyroglutamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: NaOH, H₂ / 5percent Pd/C / ethanol / 25 °C / 2172.02 - 4654.3 Torr

2: DCC / 1,2-dimethoxy-ethane; CHCl₃ / 25 °C

3: 1.) NaH / 1.) toluene, 25 deg C, 30 min, 2.) toluene, overnight

With sodium hydroxide; hydrogen; sodium hydride; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1,2-dimethoxyethane; ethanol; chloroform;
DOI:10.1021/jm00149a009

Reference yield:

: 90988-18-4,122076-80-6
N-<1(S)-(ethoxycarbonyl)-3-phenylpropyl>-(RS)-alanine

: 98049-20-8
-(R)-alanyl>-(S)-pyroglutamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: DCC / 1,2-dimethoxy-ethane; CHCl₃ / 25 °C

2: 1.) NaH / 1.) toluene, 25 deg C, 30 min, 2.) toluene, overnight

With sodium hydride; dicyclohexyl-carbodiimide; In 1,2-dimethoxyethane; chloroform;
DOI:10.1021/jm00149a009