methyl 3-(5-methyl-1-phenyl-1H-benzimidazol-2-yl)propanoate

Base Information

• Chemical Name: methyl 3-(5-methyl-1-phenyl-1H-benzimidazol-2-yl)propanoate
• CAS No.: 1613148-71-2
• Molecular Formula: C₁₈H₁₈N₂O₂
• Molecular Weight: 294.353
• Mol file: 1613148-71-2.mol

Synonyms:methyl 3-(5-methyl-1-phenyl-1H-benzimidazol-2-yl)propanoate

Chemical Property of methyl 3-(5-methyl-1-phenyl-1H-benzimidazol-2-yl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-(5-methyl-1-phenyl-1H-benzimidazol-2-yl)propanoate

There total 1 articles about methyl 3-(5-methyl-1-phenyl-1H-benzimidazol-2-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

methyl hydrogen succinate (3878-55-5) + 4-methyl-N1-phenylbenzene-1,2-diamine dihydrochloride → methyl 3-(5-methyl-1-phenyl-1H-benzimidazol-2-yl)propanoate (1613148-71-2)

Guidance literature:

methyl hydrogen succinate; 4-methyl-N¹-phenylbenzene-1,2-diamine dihydrochloride; With 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 12h;

With acetic acid; at 90 ℃; for 24h;

DOI:10.1016/j.bmc.2014.04.023

Reference yield: 81.0%

methyl 3-(5-methyl-1-phenyl-1H-benzimidazol-2-yl)propanoate (1613148-71-2) → 3-(5-methyl-1-phenyl-1H-benzimidazol-2-yl)propanoic acid (1613148-72-3)

Guidance literature:

With water; sodium hydroxide; at 20 ℃; for 20h;

DOI:10.1016/j.bmc.2014.04.023

Reference yield:

methyl 3-(5-methyl-1-phenyl-1H-benzimidazol-2-yl)propanoate (1613148-71-2) → 5-methyl-2-[2-(1-methylimidazo[1,5-a]pyridin-3-yl)ethyl]-1-phenyl-1H-benzimidazole (1613149-02-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide; water / 20 h / 20 °C

2: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate / 12 h / 80 °C

With water; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; sodium hydroxide; In ethyl acetate;

DOI:10.1016/j.bmc.2014.04.023

upstream raw materials:

methyl hydrogen succinate

Downstream raw materials:

3-(5-methyl-1-phenyl-1H-benzimidazol-2-yl)propanoic acid

5-methyl-2-[2-(1-methylimidazo[1,5-a]pyridin-3-yl)ethyl]-1-phenyl-1H-benzimidazole

2-[2-(imidazo[1,5-a]pyridin-3-yl)ethyl]-5-methyl-1-phenyl-1H-benzimidazole

7-[2-(5-methyl-1-phenyl-1H-benzimidazol-2-yl)ethyl]imidazo[1,5-b]pyridazine