(+/-)-α-[2-methoxy-3-[(1,1-dimethylethyldiphenylsilyl)oxy]phenyl]-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanone

Base Information

• Chemical Name: (+/-)-α-[2-methoxy-3-[(1,1-dimethylethyldiphenylsilyl)oxy]phenyl]-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanone
• CAS No.: 252364-42-4
• Molecular Formula: C₃₇H₄₄FNO₃Si
• Molecular Weight: 597.845

Synonyms:(+/-)-α-[2-methoxy-3-[(1,1-dimethylethyldiphenylsilyl)oxy]phenyl]-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanone

Chemical Property of (+/-)-α-[2-methoxy-3-[(1,1-dimethylethyldiphenylsilyl)oxy]phenyl]-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanone

Chemical Property:

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Technology Process of (+/-)-α-[2-methoxy-3-[(1,1-dimethylethyldiphenylsilyl)oxy]phenyl]-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanone

There total 2 articles about (+/-)-α-[2-methoxy-3-[(1,1-dimethylethyldiphenylsilyl)oxy]phenyl]-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(2-bromoethyl)-4-fluorobenzene (332-42-3) + (+/-)-α-[2-methoxy-3-[(1,1-dimethylethyl)diphenylsilyl]oxyphenyl]-4-piperidinemethanol (311348-75-1) → (+/-)-α-[2-methoxy-3-[(1,1-dimethylethyldiphenylsilyl)oxy]phenyl]-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanone (252364-42-4)

Guidance literature:

With sodium hydrogencarbonate; sodium iodide; In N,N-dimethyl-formamide; at 85 ℃; for 1.5h;

DOI:10.1016/j.bmc.2009.03.021

Reference yield:

[2-methoxy-3-[(1,1-dimethylethyldiphenylsilyl)oxy]phenyl][1-[2-(4-fluorophenyl)ethyl]-4-piperidinyl]methanone (252364-41-3) → (+/-)-α-[2-methoxy-3-[(1,1-dimethylethyldiphenylsilyl)oxy]phenyl]-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanone (252364-42-4)

Guidance literature:

With sodium tetrahydroborate; In methanol;

DOI:10.1016/j.bmcl.2007.12.054

Reference yield: 95.0%

(+/-)-α-[2-methoxy-3-[(1,1-dimethylethyldiphenylsilyl)oxy]phenyl]-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanone (252364-42-4) → MDL 104206 (1018473-89-6)

Guidance literature:

With ammonium fluoride; In methanol; at 70 ℃; for 0.25h;

DOI:10.1016/j.bmc.2009.03.021

upstream raw materials:

[2-methoxy-3-[(1,1-dimethylethyldiphenylsilyl)oxy]phenyl][1-[2-(4-fluorophenyl)ethyl]-4-piperidinyl]methanone

(2-bromoethyl)-4-fluorobenzene

(+/-)-α-[2-methoxy-3-[(1,1-dimethylethyl)diphenylsilyl]oxyphenyl]-4-piperidinemethanol

Downstream raw materials:

(R)-(+)-α-(3-hydroxy-2-methoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanone

MDL 104206

(2-methoxy-3-(tosyloxyethyloxy)phenyl)-(1-(2-p-fluorophenylethyl)-piperidine-4-yl)-methyl acetate

[3-(2-[18F]fluoroethoxy)-2-methoxyphenyl]-1-[2-(4-fluorophenyl)ethyl-4-piperidinyl]methanol

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