2-[6-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl]acetamide

Base Information

• Chemical Name: 2-[6-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl]acetamide
• CAS No.: 1258852-32-2
• Molecular Formula: C₂₄H₂₅N₅O₃
• Molecular Weight: 431.494
• Mol file: 1258852-32-2.mol

Synonyms:2-[6-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl]acetamide

Chemical Property of 2-[6-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl]acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[6-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl]acetamide

There total 8 articles about 2-[6-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

bromo-acetic acid amide (683-57-8) + 2-[(1-methylethyl)oxy]-5-[3-(2,3,4,5-tetrahydro-1H-3-benzazepin-6-yl)-1,2,4-oxadiazol-5-yl]benzonitrile mono-trifluoroacetic acid salt (1258855-43-4) → 2-[6-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl]acetamide (1258852-32-2)

Guidance literature:

With potassium carbonate; In acetone; at 90 ℃; for 0.333333h; Irradiation with microwave;

Reference yield:

3-cyano-4-isopropoxybenzoic acid (258273-31-3) → 2-[6-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl]acetamide (1258852-32-2)

Guidance literature:

Multi-step reaction with 4 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / 4 h / 20 °C

2: triethylamine / N,N-dimethyl-formamide / 3.5 h / 20 - 120 °C / Inert atmosphere

3: dichloromethane / 0 - 20 °C

4: potassium carbonate / acetone / 0.33 h / 90 °C / Irradiation with microwave

With oxalyl dichloride; potassium carbonate; triethylamine; N,N-dimethyl-formamide; In dichloromethane; N,N-dimethyl-formamide; acetone;

Reference yield:

3-cyano-4-[(1-methylethyl)oxy]benzoyl chloride (1072948-37-8) → 2-[6-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl]acetamide (1258852-32-2)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / N,N-dimethyl-formamide / 3.5 h / 20 - 120 °C / Inert atmosphere

2: dichloromethane / 0 - 20 °C

3: potassium carbonate / acetone / 0.33 h / 90 °C / Irradiation with microwave

With potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide; acetone;

upstream raw materials:

bromo-acetic acid amide

2-[(1-methylethyl)oxy]-5-[3-(2,3,4,5-tetrahydro-1H-3-benzazepin-6-yl)-1,2,4-oxadiazol-5-yl]benzonitrile mono-trifluoroacetic acid salt

3-cyano-4-isopropoxybenzoic acid

3-cyano-4-[(1-methylethyl)oxy]benzoyl chloride