2-(methylthio)ethyl 6-bromo-2,3-dihydro-α-<<<5-nitro-2,6-bis(phenylmethoxy)-4-pyrimidinyl>amino>acetyl>-2-oxo-1H-indole-3-acetate

Base Information

• Chemical Name: 2-(methylthio)ethyl 6-bromo-2,3-dihydro-α-<<<5-nitro-2,6-bis(phenylmethoxy)-4-pyrimidinyl>amino>acetyl>-2-oxo-1H-indole-3-acetate
• CAS No.: 94779-74-5
• Molecular Formula: C₃₃H₃₀BrN₅O₈S
• Molecular Weight: 736.6
• Mol file: 94779-74-5.mol

Synonyms:2-(methylthio)ethyl 6-bromo-2,3-dihydro-α-<<<5-nitro-2,6-bis(phenylmethoxy)-4-pyrimidinyl>amino>acetyl>-2-oxo-1H-indole-3-acetate

Chemical Property of 2-(methylthio)ethyl 6-bromo-2,3-dihydro-α-<<<5-nitro-2,6-bis(phenylmethoxy)-4-pyrimidinyl>amino>acetyl>-2-oxo-1H-indole-3-acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(methylthio)ethyl 6-bromo-2,3-dihydro-α-<<<5-nitro-2,6-bis(phenylmethoxy)-4-pyrimidinyl>amino>acetyl>-2-oxo-1H-indole-3-acetate

There total 7 articles about 2-(methylthio)ethyl 6-bromo-2,3-dihydro-α-<<<5-nitro-2,6-bis(phenylmethoxy)-4-pyrimidinyl>amino>acetyl>-2-oxo-1H-indole-3-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-(ethylsulfonyl)-5-nitro-2,6-bis(phenylmethoxy)pyrimidine (94219-38-2) + 2-(methylthio)ethyl α-(aminoacetyl)-6-bromo-2,3-dihydro-2-oxo-1H-indole-3-acetate hydrochloride (94779-73-4) → 2-(methylthio)ethyl 6-bromo-2,3-dihydro-α-<<<5-nitro-2,6-bis(phenylmethoxy)-4-pyrimidinyl>amino>acetyl>-2-oxo-1H-indole-3-acetate (94779-74-5)

Guidance literature:

With sodium hydrogencarbonate; In N,N-dimethyl-formamide; for 1h; Ambient temperature;

DOI:10.1016/S0040-4020(01)86989-1

Reference yield:

6-bromoisatin (6326-79-0) → 2-(methylthio)ethyl 6-bromo-2,3-dihydro-α-<<<5-nitro-2,6-bis(phenylmethoxy)-4-pyrimidinyl>amino>acetyl>-2-oxo-1H-indole-3-acetate (94779-74-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 82 percent / piperidine, acetic acid / benzene / 5 h / Heating

2: 92 percent / Na₂S₂O₄ / ethanol; H₂O / 0.08 h / Heating

3: 27 percent / NH₂NH₂*H₂O / CH₂Cl₂; methanol / 0.5 h

4: 90 percent / NaHCO₃ / dimethylformamide / 1 h / Ambient temperature

With piperidine; sodium dithionite; sodium hydrogencarbonate; hydrazine hydrate; acetic acid; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; benzene;

DOI:10.1016/S0040-4020(01)86989-1

Reference yield:

2-(methylthio)ethyl 1,3-dihydro-β,1,3-trioxo-2H-isoindole-2-butanoate (94779-70-1) → 2-(methylthio)ethyl 6-bromo-2,3-dihydro-α-<<<5-nitro-2,6-bis(phenylmethoxy)-4-pyrimidinyl>amino>acetyl>-2-oxo-1H-indole-3-acetate (94779-74-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 82 percent / piperidine, acetic acid / benzene / 5 h / Heating

2: 92 percent / Na₂S₂O₄ / ethanol; H₂O / 0.08 h / Heating

3: 27 percent / NH₂NH₂*H₂O / CH₂Cl₂; methanol / 0.5 h

4: 90 percent / NaHCO₃ / dimethylformamide / 1 h / Ambient temperature

With piperidine; sodium dithionite; sodium hydrogencarbonate; hydrazine hydrate; acetic acid; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; benzene;

DOI:10.1016/S0040-4020(01)86989-1

upstream raw materials:

4-(ethylsulfonyl)-5-nitro-2,6-bis(phenylmethoxy)pyrimidine

2-(methylthio)ethyl α-(aminoacetyl)-6-bromo-2,3-dihydro-2-oxo-1H-indole-3-acetate hydrochloride

6-bromoisatin

2-(methylthio)ethyl 1,3-dihydro-β,1,3-trioxo-2H-isoindole-2-butanoate

Downstream raw materials:

C₄₂H₃₈BrN₅O₁₀S

C₅₆H₅₈BrN₅O₁₆

C₅₀H₅₂BrN₅O₁₃

C₄₂H₃₈BrN₅O₁₂S