(10)N-formylaminopterin α-benzyl ester γ-tert-butylamide hemi p-toluenesulfonate salts

Base Information

Chemical Name:(10)N-formylaminopterin α-benzyl ester γ-tert-butylamide hemi p-toluenesulfonate salts
CAS No.:102650-96-4
Molecular Formula:C₇H₈O₃S*2C₃₁H₃₅N₉O₅
Molecular Weight:1399.56
Hs Code.:

Synonyms:(10)N-formylaminopterin α-benzyl ester γ-tert-butylamide hemi p-toluenesulfonate salts

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Chemical Property of (10)N-formylaminopterin α-benzyl ester γ-tert-butylamide hemi p-toluenesulfonate salts

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Technology Process of (10)N-formylaminopterin α-benzyl ester γ-tert-butylamide hemi p-toluenesulfonate salts

There total 4 articles about (10)N-formylaminopterin α-benzyl ester γ-tert-butylamide hemi p-toluenesulfonate salts which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 89043-75-4
4-amino-4-deoxy-N¹⁰-formylpteroic acid

: 102651-12-7
L-glutamic acid α-benzyl ester γ-tert-butylamide p-toluenesulfonate salt

: 102650-96-4
(10)N-formylaminopterin α-benzyl ester γ-tert-butylamide hemi p-toluenesulfonate salts

Guidance literature:: With triethylamine; isobutyl chloroformate; In water; N,N-dimethyl-formamide; for 75h; Ambient temperature;
DOI:10.1021/jm00159a023

Reference yield:

: 30924-93-7
Boc-Glu-OBn

: 102650-96-4
(10)N-formylaminopterin α-benzyl ester γ-tert-butylamide hemi p-toluenesulfonate salts

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / diphenylphosphorylazide, Et₂N / dimethylformamide / 45 h / 0 - 25 °C

2: 94 percent / benzene / 1 h / Heating

3: 71 percent / i-BuOCOCl, Et₃N / dimethylformamide; H₂O / 75 h / Ambient temperature

With diphenylphosphoranyl azide; diethylamine; triethylamine; isobutyl chloroformate; In water; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00159a023

Reference yield:

: 104-15-4
toluene-4-sulfonic acid

: 102650-96-4
(10)N-formylaminopterin α-benzyl ester γ-tert-butylamide hemi p-toluenesulfonate salts

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / benzene / 1 h / Heating

2: 71 percent / i-BuOCOCl, Et₃N / dimethylformamide; H₂O / 75 h / Ambient temperature

With triethylamine; isobutyl chloroformate; In water; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00159a023